Circadian and ultradian rhythms in normal mice and in a mouse model of Huntington's disease.
Circadian and ultradian rhythms in normal mice and in a mouse model of Huntington's disease.
复制标题
正常小鼠和亨廷顿病小鼠模型的昼夜节律和超昼夜节律。
DOI：
10.1080/07420528.2021.2014516
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发表时间：
2022
影响因子：
2.8
通讯作者：
Garfinkel,Alan
中科院分区：
文献类型：
--
作者：
Griffis,ChristopherG;Mistry,Janki;Islam,Kendall;Cutler,Tamara;Colwell,ChristopherS;Garfinkel,Alan
核心体温(CBT)的昼夜节律已被广泛研究，但对高频(超高频)节律的详细研究较少。我们分析了来自年轻和中年野生型小鼠以及亨廷顿病(HD)Q175模型的CBT记录，在足够的时间分辨率下解决了超常节律的问题。我们使用模型选择方法表明，方波比正弦波更适合整体昼夜节律模式。然后，使用CBT节律的傅里叶分析，我们确定了8小时振荡的光谱特征，该振荡发生在夜间，而不是白天，这一观察结果可以通过直接检查节律来证实。这种对8小时节律的昼夜幅度调制随着年龄的增长而消失，在HD模型中也是如此。因此，衰老和疾病的影响在这里表现为丧失将节律分为白天阶段和夜间阶段的能力。这些发现提出了这样一种可能性，即CBT中的超常节律可能是中枢神经系统内病理的有用生物标志物。
Circadian rhythms in core body temperature (CBT) have been widely studied, but fewer studies have explored higher-frequency (ultradian) rhythms in detail. We analyzed CBT recordings from young and middle-aged wild-type mice as well as from the Q175 model of Huntington’s disease (HD), at sufficient temporal resolution to address the question of ultradian rhythms. We used model selection methods to show that the overall circadian pattern was better fit by a square wave than a sine wave. Then, using Fourier analysis of the CBT rhythms, we identified the spectral signature of an 8-hour oscillation that occurs in the night but not the day, an observation that can be confirmed by direct inspection of the rhythms. This diurnal amplitude modulation of the 8-hour rhythm was lost with aging as well as in the HD model. Thus, the impact of aging and disease is seen here in the loss of the ability to separate rhythms into a daytime phase and a nighttime phase. These findings raise the possibility that ultradian rhythms in CBT may be a useful biomarker for the pathology within the central nervous system.