LACTATE RISE DETECTED BY H-1-NMR IN HUMAN VISUAL-CORTEX DURING PHYSIOLOGICAL STIMULATION
LACTATE RISE DETECTED BY H-1-NMR IN HUMAN VISUAL-CORTEX DURING PHYSIOLOGICAL STIMULATION
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DOI：
10.1073/pnas.88.13.5829
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发表时间：
1991-07-01
影响因子：
11.1
通讯作者：
SHULMAN, R
中科院分区：
文献类型：
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作者：
PRICHARD, J;ROTHMAN, D;SHULMAN, R
脑乳酸浓度通常被认为是稳定的，除非病理条件导致糖酵解和呼吸之间的不匹配。使用新开发的H-1 NMR光谱技术，允许在体内的乳酸测量，我们检测到乳酸升高0.3-0.9 mM在人类视觉皮层在生理光刺激。最大的上升出现在最初的几分钟，此后乳酸浓度下降，而刺激继续。结果是一致的短暂过量的糖酵解呼吸在视觉皮层，发生作为一个正常的反应，刺激在生理范围内。
Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed H-1 NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.