Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
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DOI：
10.1136/bmjopen-2016-015136
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发表时间：
2017-08-01
期刊：
影响因子：
2.9
通讯作者：
Brakenridge SC
中科院分区：
文献类型：
--
作者：
Loftus TJ;Mira JC;Ozrazgat-Baslanti T;Ghita GL;Wang Z;Stortz JA;Brumback BA;Bihorac A;Segal MS;Anton SD;Leeuwenburgh C;Mohr AM;Efron PA;Moldawer LL;Moore FA;Brakenridge SC
脓毒症是创伤和手术患者中常见的、昂贵的和病态的危重病原因。脓毒症复苏和重症监护支持策略的持续进展已导致住院死亡率的改善。然而，这些患者现在存活进入慢性危重病（CCI）状态，持续的低度器官功能障碍和由持续性炎症，免疫抑制和卡他综合征（PICS）驱动的不良长期结局。脓毒症和危重病研究中心（SCIRC）的创建是为了提供一个平台，通过这个平台，可以在多个医学学科的机制水平上了解CCI和PICS的患病率和发病机制，从而开发新的管理策略和靶向治疗。在这里，我们描述了设计，研究队列和标准操作程序中使用的前瞻性研究，人类败血症在1级创伤中心和三级护理医院提供护理，每年超过2600名重症患者。这些程序包括实施自动化脓毒症监测计划，通过计算机化脓毒症方案增强临床决策，将电子病历中的质量过滤数据直接导出到研究数据库的策略以及强大的长期随访。本研究已在ClinicalTrials.gov上注册，并获得佛罗里达大学机构审查委员会的批准，正在积极招募受试者。即将公布结果。
Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic critical illness (CCI), persistent low-grade organ dysfunction and poor long-term outcomes driven by the persistent inflammation, immunosuppression and catabolism syndrome (PICS). The Sepsis and Critical Illness Research Center (SCIRC) was created to provide a platform by which the prevalence and pathogenesis of CCI and PICS may be understood at a mechanistic level across multiple medical disciplines, leading to the development of novel management strategies and targeted therapies. Here, we describe the design, study cohort and standard operating procedures used in the prospective study of human sepsis at a level 1 trauma centre and tertiary care hospital providing care for over 2600 critically ill patients annually. These procedures include implementation of an automated sepsis surveillance initiative, augmentation of clinical decisions with a computerised sepsis protocol, strategies for direct exportation of quality-filtered data from the electronic medical record to a research database and robust long-term follow-up. This study has been registered at ClinicalTrials.gov, approved by the University of Florida Institutional Review Board and is actively enrolling subjects. Dissemination of results is forthcoming.
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幸存的败血症运动：严重败血症和化粪池冲击管理的国际指南，2012年。
影响因子：
38.9
作者：
Dellinger RP;Levy MM;Rhodes A;Annane D;Gerlach H;Opal SM;Sevransky JE;Sprung CL;Douglas IS;Jaeschke R;Osborn TM;Nunnally ME;Townsend SR;Reinhart K;Kleinpell RM;Angus DC;Deutschman CS;Machado FR;Rubenfeld GD;Webb S;Beale RJ;Vincent JL;Moreno R;Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
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Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
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影响因子：
8.8
作者：
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通讯作者：
Moldawer LL
DOI：
10.1097/01.ta.0000225933.08478.65
发表时间：
2006-07-01
影响因子：
--
作者：
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通讯作者：
Maier, Ronald V.
影响因子：
8.8
作者：
Ely, EW;Margolin, R;Inouye, SK
通讯作者：
Inouye, SK
影响因子：
7.2
作者：
McDowell, I;Kristjansson, B;Hebert, R
通讯作者：
Hebert, R