Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor
Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor
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Proversilins A-E，来自内生杂色曲霉的 Drimane 型倍半萜类化合物
DOI：
10.1021/acs.jnatprod.0c00298
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发表时间：
2020-07-24
影响因子：
5.1
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Li, Huaqiang;Zhang, Runge;Zhang, Yonghui
从石蒜（Lycoris radiata）鳞茎内生真菌Aspergillus versicolor F210中分离得到5个新的补身烷型倍半萜，命名为proversilinsA-E（1-5）。它们的结构和绝对构型的特征在于广泛的光谱分析，包括1D和2D NMR和HRESIMS数据，实验和计算的电子圆二色性数据的比较，和X射线晶体学。前体蛋白B-E（2-5）代表了以N-乙酰基-β-苯丙氨酸部分为特征的天然产物的第一个实例。化合物3和5抑制HL-60细胞的生长，IC 50值分别为7.3和9.9 μ M。
Five new drimane-type sesquiterpenoids, named proversilins A-E (1-5), were isolated from the endophytic fungus Aspergillus versicolor F210 isolated from the bulbs of Lycoris radiata. Their structures and absolute configurations were characterized by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data, comparison of experimental and calculated electronic circular dichroism data, and X-ray crystallography. Proversilins B-E (2-5) represent the first examples of natural products featuring an N-acetyl-beta-phenylalanine moiety. Compounds 3 and 5 inhibited the growth of HL-60 cells with IC50 values of 7.3 and 9.9 mu M, respectively.