Endemic nephropathy and upper urothelial carcinoma--new insights in molecular biology.
Endemic nephropathy and upper urothelial carcinoma--new insights in molecular biology.
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地方性肾病和上尿路上皮癌——分子生物学的新见解。
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
V. Stefanović
中科院分区：
文献类型：
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作者：
L. Janković Veličković;Z. Dolicanin;V. Stefanović
上尿路上皮癌（Upper Tract Urothelial Carcinoma，UTUC）是一种少见的疾病，在世界上巴尔干半岛的国家的某些地区发病率较高。在BEN流行的南摩拉瓦河流域及其支流对UTUC的调查显示，不仅肾盂和输尿管肿瘤的发生频率增加，而且膀胱肿瘤的发生频率也增加。在BEN地区和对照农村和城市人口的UTUC的比较形态学和免疫组织化学研究BEN，确定生长模式作为区分BEN和对照肿瘤的最佳形态学特征，即BEN肿瘤的实体生长和对照肿瘤的乳头状生长。在BEN肿瘤中检测到肿瘤抑制基因p53的过度表达以及E-CD表达的降低。其他细胞周期相关的分子标志物--Cyclin D1、p16和HER-2以及增殖标志物Ki-67在组间的表达没有差异。对膀胱癌相关标志物的研究表明Bax是BEN相关UTUC的特异性标志物。促凋亡蛋白Bax的减少与Survivin的改变一起可能是UTUC流行地区产生的内在凋亡途径的特异性紊乱的指示。
Upper Tract Urothelial Carcinoma (UTUC) is an uncommon disease which occurs more frequently in some regions of Balkan countries than in other areas in the world. Investigation of UTUC in the South Morava River basin and its tributaries where BEN is endemic revealed increased frequency not only of tumour of the renal pelvis and ureter but also of urinary bladder tumours. A comparative morphological and immunohistochemical study of UTUC in the BEN region and control rural and city populations free of BEN, identify growth pattern as the best morphological characteristic which differentiated BEN and control tumours, i.e. solid growth for BEN tumours and papillary for control tumours. Overexpression of tumour suppressor p53 as well as decreased expression of E-CD was detected in BEN tumours. Other cells cycle related molecular markers--Cyclin D1, p16, and HER-2 showed no difference in expression between groups, as well as the proliferative marker Ki-67. Investigation of apoptosis-related markers identifies Bax as a specific marker of BEN-associated UTUC. Decrease of the pro-apoptotic protein Bax together with alteration of Survivin may be indicative of specific disturbances of an intrinsic apoptotic pathway in UTUC arising in endemic areas.