Physiological aspects of membrane lipid fluidity in malignancy.
Physiological aspects of membrane lipid fluidity in malignancy.
复制标题
恶性肿瘤中膜脂流动性的生理方面。
DOI：
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发表时间：
1987
影响因子：
2
通讯作者：
G. Deliconstantinos
中科院分区：
文献类型：
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作者：
G. Deliconstantinos
膜脂双层流动性在多种生物活性分子的信号转导中起着至关重要的作用，这些分子可激活细胞功能、细胞分化和增殖。关于膜流动性改变的方向，在肿瘤中没有可辨别的总体趋势。在肝癌中，膜流动性降低，而在神经肿瘤、淋巴瘤和白血病中，膜流动性似乎增加。癌细胞的转移能力似乎与膜脂的流动性程度有关。癌细胞质膜含有通过改变流动性而暴露的隐性反向抗原的可能性，引发了治疗肿瘤疾病的潜在新方法。进一步探索生物活性物质改变膜流动性的机制，可能为理解肿瘤生长和癌症转移的机制提供线索。
Membrane lipid bilayer fluidity has a crucial role in signal transduction for a variety of biologically active molecules which activate cellular functions, cell differentiation and proliferation. No general trend is discernible in tumors regarding the direction of alteration in membrane fluidity. In hepatomas, the membrane fluidity decreases, whereas in neural tumors, lymphomas and leukemias, the membrane fluidity seems increased. The capability of cancer cells to metastasize seems to be related to the degree of membrane lipid fluidity. The possibility that cancer cell plasma membrane contains cryptic antidromic antigens becoming exposed by altering the fluidity, has triggered a potentially new approach in the treatment of neoplastic diseases. Further exploration into the mechanisms by which biologically active substances alter the membrane fluidity, may provide clues for understanding the mechanism of tumor growth and cancer metastases.