Prenatal drug exposure and executive function in early adolescence.
Prenatal drug exposure and executive function in early adolescence.
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DOI：
10.1016/j.ntt.2021.107036
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发表时间：
2021-11
影响因子：
2.9
通讯作者：
Lewis M
中科院分区：
文献类型：
--
作者：
Karpova N;Zhang D;Beckwith AM;Bennett DS;Lewis M
关于产前可卡因暴露（PCE）与执行功能（EF）之间关系的研究得出了不一致的结果。本研究的目的是检查PCE，生物性别，环境风险，以及它们的相互作用是否预测青春期早期的EF。135名12岁的青少年（40.7%患有PCE），从出生起就进行前瞻性随访，尝试了多达8次复杂性不断增加的河内塔（ToH）难题试验。正确完成谜题的数量作为主要的结果测量。生存分析用于检查成功完成试验数量的预测因素。随着试验难度的增加，能够解决TOH难题的青少年越来越少。来自高风险环境的青少年，无论是产前酒精或产前大麻暴露完成较少的难题（p<0.05）。此外，还发现PCE ×性别×环境风险的假设三因素相互作用，即高环境风险的可卡因暴露男性表现最差（p<.01）。目前的研究结果是一致的，与先前的研究表明，男性与PCE可能是在特定的风险较差的功能，并强调检查青少年的性别和环境风险作为调节剂的PCE效应的潜在重要性。
Study of the relationship between prenatal cocaine exposure (PCE) and executive function (EF) has yielded inconsistent results. The purpose of the current study is to examine whether PCE, biological sex, environmental risk, and their interaction predicted EF in early adolescence. 135 12-year-old adolescents (40.7% with PCE), who were followed prospectively from birth, attempted up to 8 Tower of Hanoi (ToH) puzzle trials of increasing complexity. The number of correctly completed puzzles served as the main outcome measure. Survival analysis was used to examine predictors of the number of successfully completed trials. As trial difficulty increased, fewer adolescents were able to solve the TOH puzzle. Adolescents from high risk environments and with either prenatal alcohol or prenatal cannabis exposure completed fewer puzzles (p<.05). In addition, a hypothesized 3-way interaction of PCE × sex × environmental risk was found such that cocaine-exposed males with high environmental risk had the worst performance (p<.01). The current findings are consistent with prior research indicating that males with PCE may be at particular risk of poorer functioning and highlight the potential importance of examining adolescent’s sex and environmental risk as moderators of PCE effects.
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影响因子：
2.9
作者：
Chiriboga, Claudia A.;Kuhn, Louise;Wasserman, Gail A.
通讯作者：
Wasserman, Gail A.
影响因子：
8
作者：
Bateman, DA;Chiriboga, CA
通讯作者：
Chiriboga, CA
影响因子：
4
作者：
BENDERSKY, M;LEWIS, M
通讯作者：
LEWIS, M
影响因子：
4
作者：
Bendersky, M;Lewis, M
通讯作者：
Lewis, M
宫内可卡因的暴露和童年中期的高管功能。
影响因子：
2.9
作者：
Rose-Jacobs, Ruth;Waber, Deborah;Beeghly, Marjorie;Cabral, Howard;Appugleise, Danielle;Heeren, Timothy;Marani, Jodi;Frank, Deborah A.
通讯作者：
Frank, Deborah A.