Effect of tumor promoters on induction of aryl hydrocarbon hydroxylase in human lymphocytes.
Effect of tumor promoters on induction of aryl hydrocarbon hydroxylase in human lymphocytes.
复制标题
肿瘤启动子对人淋巴细胞中芳烃羟化酶诱导的影响。
DOI：
10.1159/000459274
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Acs,G
中科院分区：
文献类型：
--
作者：
Kyner,D;Christman,JK;Acs,G
淋巴细胞中芳烃羟基酶的诱导依赖于它们的激活。促进肿瘤的佛波酯在淋巴细胞中诱导原始细胞的形成和DNA的合成，使多环芳烃能够诱导芳烃羟基酶。蜂毒素是蜂毒的主要成分，与这些佛波酯具有协同作用，可以促进淋巴细胞激活和羟基酶的合成。由于芳烃羟基酶将致癌物转化为致癌物，这些结果表明佛波酯的促癌作用可能与其影响这些酶的诱导有关。这一假说得到以下发现的支持：缺乏肿瘤促进活性的佛波酯和佛波酯不能增强淋巴细胞中芳烃羟基酶的诱导。然而，尽管美策林在促进肿瘤方面相当无效，但它可以激活淋巴细胞，并允许多环芳烃有效地诱导它们的羟基酶。
The induction of aryl hydrocarbon hydroxylases in lymphocytes is dependent on their activation. The tumor-promoting phorbol esters which induce blast formation and DNA synthesis in lymphocytes enable polycyclic aromatic hydrocarbons to induce aryl hydrocarbon hydroxylases. Melittin, the major constituent of bee venom, acts synergistically with these phorbol esters in enhancing both lymphocyte activation and hydroxylase synthesis. Since aryl hydrocarbon hydroxylases convert procarcinogens to carcinogens these results suggest that tumor promotion by phorbol esters may be associated with their ability to affect the induction of these enzymes. This hypothesis is supported by the finding that phorbol and phorbol esters which lack tumor-promoting activity fail to enhance induction of aryl hydrocarbon hydroxylases in lymphocytes. However mezerein, although rather ineffective in promoting tumors, activates lymphocytes and permits polycyclic aromatic hydrocarbons to induce their hydroxylases effectively.