Short-term effects of transdermal nicotine on acute tissue plasminogen activator release in vivo in man
Short-term effects of transdermal nicotine on acute tissue plasminogen activator release in vivo in man
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DOI：
10.1016/s0008-6363(01)00381-9
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发表时间：
2001-11-01
影响因子：
10.8
通讯作者：
Webb, DJ
中科院分区：
文献类型：
--
作者：
Pellegrini, MP;Newby, DE;Webb, DJ
目的：吸烟损害外周内皮依赖性血管舒张和急性组织纤溶酶原激活物（t-PA）释放的man. The研究的目的是确定这种内皮功能障碍，部分是由尼古丁的影响介导的。研究方法：血流量和血浆纤溶因子测定在两个前臂的8名健康男性非吸烟者在单侧肱动脉灌注的内皮依赖性血管扩张剂，P物质（2至8 pmol/min）。通过动脉内输注硝普钠（2 - 8 μ g/min）评估内皮非依赖性血管舒张。在双盲随机交叉设计中，受试者在接受经皮尼古丁或安慰剂治疗7天后参加研究。结果：尼古丁给药期间，血浆可替宁浓度从0.4+/-0.1（安慰剂）升高至125+/-25 ng/ml（P
Objective: Cigarette smoking impairs peripheral endothelium-dependent vasodilatation and acute tissue plasminogen activator (t-PA) release in man. The aim of the study was to determine if this endothelial dysfunction is, in part, mediated by the effects of nicotine. Methods: Blood flow and plasma fibrinolytic factors were measured in both forearms of eight healthy male non-smokers during unilateral brachial artery infusion of the endothelium-dependent vasodilator, substance P (2 to 8 pmol/min). Endothelium-independent vasodilatation was assessed using intra-arterial infusion of sodium nitroprusside (2 to 8 mug/min). Subjects attended after 7 days treatment with transdermal nicotine or placebo in a double blind randomised crossover design. Results: Plasma cotinine concentrations rose from 0.4+/-0.1 (placebo) to 125+/-25 ng/ml during nicotine administration (P