Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity - Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity - Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
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DOI：
10.2337/diacare.23.1.57
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发表时间：
2000-01-01
期刊：
影响因子：
16.2
通讯作者：
Muggeo, M
中科院分区：
文献类型：
--
作者：
Bonora, E;Saggiani, F;Muggeo, M
目的-评价稳态模型评估（HOMA）是否是人体体内胰岛素敏感性的可靠替代指标。研究设计和方法-在本研究中）：我们比较了胰岛素敏感性，（类似于5 mmol/l）高胰岛素血症（类似于300 pmol/l）钳与HOMA在115例受试者与不同程度的葡萄糖耐量和胰岛素敏感性。测量的总葡萄糖处置和HOMA估计的胰岛素敏感性（r =-0.820，P < 0.0001），在男性（r = -0.800）和女性（r = -0.796）之间没有实质性差异，年轻（老年）
QBJECTIVE- To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.RESEARCH DESIGN AND METHODS- In the present stud): we compared insulin sensitivity as assessed by a 4-h euglycemic (similar to 5 mmol/l) hyperinsulinemic (similar to 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity.RESULTS- We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P < 0.0001), with no substantial differences between men (r = -0.800) and women (r = -0.796), younger (aged