Burn control, an adipocyte-specific function for galectin-12.
Burn control, an adipocyte-specific function for galectin-12.
复制标题
烧伤控制，半乳糖凝集素 12 的脂肪细胞特异性功能。
DOI：
10.1073/pnas.1115738108
复制
发表时间：
2011
影响因子：
11.1
通讯作者：
Baum,LindaG
中科院分区：
文献类型：
--
作者：
Baum,LindaG
分子家族通常具有相似的功能——想想激酶、转录因子、趋化因子或toll样受体。凝集素是一种进化上古老的碳水化合物结合蛋白家族，存在于从多细胞真菌到人类的生物体中，但却有所不同（1,2）。凝集素是凝集素的一个家族；该家族的命名是基于高度保守的结构特征，特别是保守的碳水化合物识别结构域（CRDs），将蛋白质定义为凝集素。相比之下，凝集素的多效性功能似乎并不保守。根据所研究的细胞类型，已报道了半乳糖凝集素调节细胞增殖、迁移、粘附、分化、存活和死亡，并积极或消极地调节宿主对微生物病原体的防御。凝集素的细胞外功能通常取决于凝集素的碳水化合物结合特性，但如果各种凝集素能够识别许多不同的糖蛋白受体，如果这些糖蛋白受体具有合适的糖配体，那么就可以通过凝集素结合触发大量的细胞功能。此外，细胞内也发现了半乳糖凝集素，例如，在质膜、细胞核和线粒体的细胞质面，蛋白质-蛋白质相互作用促进半乳糖凝集素-3与K-Ras、β-catenin和Bcl-2家族成员的关联，以调节肿瘤发生和细胞死亡（3-5）。在《美国科学院院刊》上，Yang等人(6)的研究报告了一种名为galectin-12的细胞聚集素在一个意想不到的亚细胞位置上具有意想不到的功能。
Families of molecules often have similar functions—think of kinases, transcription factors, chemokines, or Toll-like receptors. The galectins, an evolutionarily ancient family of carbohydrate binding proteins found in organisms from multicellular fungi to humans, are different (1, 2). Galectins are a family of lectins; the family designation is based on highly conserved structural features, particularly the conserved carbohydrate recognition domains (CRDs) that define the proteins as lectins. In contrast, the pleiotropic functions of galectins do not seem to be conserved. Based on the cell type investigated, galectins have been reported to regulate cell proliferation, migration, adhesion, differentiation, survival, and death, and they also positively and negatively regulate host defense against microbial pathogens. Extracellular functions of galectins typically depend on the carbohydrate binding properties of the lectins, but many different glycoprotein receptors can be recognized by various galectins if the glycoprotein receptors bear the appropriate glycan ligands, resulting in the vast array of cellular functions triggered by galectin binding. In addition, galectins are also found intracellularly, where for example, protein–protein interactions at the cytoplasmic face of the plasma membrane, nucleus, and mitochondria promote association of galectin-3 with K-Ras, β-catenin, and Bcl-2 family members to regulate oncogenesis and cell death (3–5). In PNAS, the work by Yang et al.(6) reports an unexpected function for a galectin, galectin-12, at an unexpected subcellular location.