Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity
Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity
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DOI：
10.1093/cercor/bhx353
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发表时间：
2019-02
期刊：
影响因子：
3.7
通讯作者：
Matthias F. J. Sperl;Christian Panitz;I. Rosso;D. Dillon;Poornima Kumar;A. Hermann;Alexis E. Whitton;C. Hermann;D. Pizzagalli;E. M. Mueller
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文献类型：
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作者：
Matthias F. J. Sperl;Christian Panitz;I. Rosso;D. Dillon;Poornima Kumar;A. Hermann;Alexis E. Whitton;C. Hermann;D. Pizzagalli;E. M. Mueller
人类功能性磁共振成像（fMRI）和脑电图（EEG）研究以及动物研究表明，杏仁核和前内侧脑区与条件性恐惧密切相关，并且θ范围（4-8 Hz）的前内侧振荡可能支持这些脑区之间的通信。然而，很少有研究使用多模态方法来探测人类这些关键区域之间的相互作用。在这里，我们的目标是弥合人类功能磁共振成像，脑电图和动物发现之间的差距。使用同步脑电图功能磁共振成像记录24小时后，恐惧条件化和灭绝，条件刺激（CS+E，CS-E）和不存在灭绝（CS+N，CS-N）进行了比较，以确定特定的效果与恐惧回忆灭绝。微分（CS+与CS-）皮肤电，frontomedial θ（EEG）和杏仁核反应（fMRI）减少熄灭与非熄灭的刺激。重要的是，对θ功率的影响与对杏仁核激活的影响共变。恐惧和灭绝回忆，如西塔所示，解释了60%的变异，为类似的影响，在右侧杏仁核。我们的研究结果首次显示了人类在恐惧和灭绝回忆过程中杏仁核和前内侧θ活动的相互作用，并提供了对啮齿动物中与自上而下杏仁核调制一致相关的神经回路的深入了解。
Human functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) studies, as well as animal studies, indicate that the amygdala and frontomedial brain regions are critically involved in conditioned fear and that frontomedial oscillations in the theta range (4-8 Hz) may support communication between these brain regions. However, few studies have used a multimodal approach to probe interactions among these key regions in humans. Here, our goal was to bridge the gap between prior human fMRI, EEG, and animal findings. Using simultaneous EEG-fMRI recordings 24 h after fear conditioning and extinction, conditioned stimuli presented (CS+E, CS-E) and not presented during extinction (CS+N, CS-N) were compared to identify effects specific to extinction versus fear recall. Differential (CS+ vs. CS-) electrodermal, frontomedial theta (EEG) and amygdala responses (fMRI) were reduced for extinguished versus nonextinguished stimuli. Importantly, effects on theta power covaried with effects on amygdala activation. Fear and extinction recall as indicated by theta explained 60% of the variance for the analogous effect in the right amygdala. Our findings show for the first time the interplay of amygdala and frontomedial theta activity during fear and extinction recall in humans and provide insight into neural circuits consistently linked with top-down amygdala modulation in rodents.