Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
复制标题
DOI：
10.1016/j.neuropharm.2004.06.030
复制
发表时间：
2004-10-01
影响因子：
4.7
通讯作者：
Jia, ZP
中科院分区：
文献类型：
--
作者：
Meng, YH;Takahashi, H;Jia, ZP
为了研究LIMK家族在调节哺乳动物中枢神经系统（CNS）中ADF/cofilin磷酸化和突触功能中的作用，我们使用LIMK-1和LIMK-2表达发生遗传改变的小鼠进行生物化学和电生理学分析。我们在这里表明，虽然LIMK-2敲除小鼠表现出最小的异常，但LIMK-1/2双敲除小鼠在海马CA 1区的ADF/cofilin磷酸化和兴奋性突触功能方面受到更严重的损害。这些结果表明LIMK家族在调节ADF/cofilin和脑中的突触功能中起关键作用。(C)2004 Elsevier Ltd.保留所有权利。
To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-I and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results Indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain. (C) 2004 Elsevier Ltd. All rights reserved.