Unusually high susceptibility of NZR/Gd rats to bladder cancer induction by low doses of nitrosomethylurea.
Unusually high susceptibility of NZR/Gd rats to bladder cancer induction by low doses of nitrosomethylurea.
复制标题
NZR/Gd 大鼠对低剂量亚硝基甲基脲诱发膀胱癌的敏感性异常高。
DOI：
10.1016/0304-3835(84)90118-6
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发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
K. Beagley
中科院分区：
文献类型：
--
作者：
R. Noronha;L. Horne;C. Goodall;K. Beagley
NZR Gd品系的近交雌性大鼠在膀胱内滴注后对亚硝基甲脲（NMU）毒性异常敏感。在10个部分中总共给予1.0 mg NMU后，100%的NZR大鼠发生恶性膀胱肿瘤。当NMU给药间隔为2周时，移行细胞癌占主导地位（56%），大多数肿瘤为鳞状细胞癌（57%），间隔为1周。
Inbred female rats of the NZR Gd strain were exceptionally susceptible to nitrosomethylurea (NMU) toxicity after intravesical instillations. After only 1.0 mg NMU total given in 10 fractions, 100% of NZR rats developed malignant bladder tumours. Transitional cell carcinomas predominated (56%) when the NMU dose interval was 2 weeks, and most tumours were squamous carcinomas (57%) with a 1-week interval.