Fungus spores, air pollutants, and other determinants of peak expiratory flow rate in children
Fungus spores, air pollutants, and other determinants of peak expiratory flow rate in children
复制标题
DOI：
10.1093/oxfordjournals.aje.a008818
复制
发表时间：
1996-04-15
影响因子：
5
通讯作者：
Speizer, FE
中科院分区：
文献类型：
--
作者：
Neas, LM;Dockery, DW;Speizer, FE
1991年夏天，对生活在宾夕法尼亚州立大学的108名儿童进行了一项研究，探讨了夏季雾霾发作对症状和呼气峰流速（PEFR）每日变化的影响。每天两次，每个孩子记录症状，PEFR和户外活动时间。环境测量包括气象和空气污染物变量的每日12小时和24小时平均值以及24小时平均真菌孢子浓度。枝孢菌孢子浓度增加10，000个孢子/m3与早晨PEFR不足相关（-1.0升/分钟，95%置信区间（CI）-1.9至-0.2）。附球菌孢子浓度增加60个孢子/m（3）与早晨咳嗽发生率增加（比值比（OR）= 1.8，95%CI 1.0-3.2）和早晨PEFR不足（-1.5升/分钟，95%CI-2.8至-0.2）相关。真菌孢子计数与可吸入颗粒物质量无关。12小时白天强酸性颗粒物浓度增加125 nmol/m3与夜间PEFR不足（-0.5升/分钟，95% CI -1.2至0.2）以及当晚或次日早晨感冒发作的发生率增加（OR = 1.35，95% CI 1.14-1.61）相关。滞后24小时的24小时可吸入颗粒物增加20 μ g/m3与夜间PEFR不足（-0.5升/分钟，95%CI-1.4至0.4）和当晚或次日早晨咳嗽发作发生率增加（OR = 1.37，95%CI 1.13-1.66）相关。这些结果证实了夏季颗粒空气污染的急性影响，并表明空气过敏原对儿童呼吸道症状和PEFR有独立的影响。
The impact of summertime haze episodes on daily variations in symptoms and peak expiratory flow rates (PEFRs) was examined in a study of 108 children living in State College, Pennsylvania, during the summer of 1991. Twice daily, each child recorded symptoms, PEFRs, and hours spent outdoors. Environmental measurements included daily 12- and 24-hour averages for meteorologic and air pollutant variables and 24-hour average fungus spore concentrations. A 10,000-spore/m(3) increment in Cladosporium spore concentration was associated with a deficit in morning PEFR (-1.0 liters/minute, 95% confidence interval (CI) -1.9 to -0.2). A 60-spore/m(3) increment in Epicoccum spore concentration was associated with increased incidence of morning cough (odds ratio (OR) = 1.8, 95% CI 1.0-3.2) and a deficit in morning PEFR (-1.5 liters/minute, 95% CI -2.8 to -0.2). Fungi spore counts were not associated with respirable particle mass. A 125-nmol/m(3) increment in 12-hour daytime particle-strong acidity was associated with a deficit in evening PEFR (-0.5 liters/minute, 95% CI -1.2 to 0.2) and increased incidence of cold episodes that evening or the subsequent morning (OR = 1.35, 95% CI 1.14-1.61). A 20-mu g/m(3) increment in 24-hour respirable particles lagged by 24 hours was associated with a deficit in evening PEFR (-0.5 liters/minute, 95% CI -1.4 to 0.4) and increased incidence of cough episodes that evening or the subsequent morning (OR = 1.37, 95% CI 1.13-1.66). These results confirm the acute effects of summertime particulate air pollution and suggest that aeroallergens have independent effects on respiratory symptoms and PEFR in children.