Central nervous system action of corticotropin-releasing factor to inhibit gastric emptying in rats.
Central nervous system action of corticotropin-releasing factor to inhibit gastric emptying in rats.
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促肾上腺皮质激素释放因子抑制大鼠胃排空的中枢神经系统作用。
DOI：
10.1152/ajpgi.1987.253.2.g241
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Turkelson,CM
中科院分区：
文献类型：
--
作者：
Taché,Y;Maeda-Hagiwara,M;Turkelson,CM
本文用酚红法研究了大鼠促肾上腺皮质激素释放因子（CRF）对清醒大鼠液体胃排空的中枢作用。脑池内注射CRF（63-210 pmol）剂量依赖性地抑制胃排空的液体餐的37- 80%。肽的作用是快速的，长期的作用，而不是模仿脑池内注射的生长激素释放因子。脑池内CRF诱导的胃排空抑制可被迷走神经切断术逆转，但不被纳洛酮预处理或肾上腺切除术逆转。静脉注射CRF（21-630 pmol）也呈剂量依赖性地抑制胃排空。CRF抗血清阻断静脉注射CRF（63 pmol），但不阻断脑池内注射CRF的作用。这些结果表明，以皮摩尔量注射到脑脊液中的CRF在脑内通过迷走神经依赖性途径抑制胃排空液体食物。
The present study evaluates the central nervous system action of rat corticotropin-releasing factor (CRF) on gastric emptying of a liquid meal in conscious rats using the phenol red method. Intracisternal injection of CRF (63-210 pmol) dose-dependently inhibited gastric emptying of a liquid meal by 37-80%. Peptide action was rapid in onset, long acting, and not mimicked by intracisternal injection of growth hormone-releasing factor. Intracisternal CRF-induced inhibition of gastric emptying was reversed by subdiaphragmatic vagotomy but not by naloxone pretreatment or adrenalectomy. Intravenous injection of CRF (21-630 pmol) also dose-dependently inhibited gastric emptying. CRF antiserum blocked the effect of intravenous but not of intracisternal injection of CRF (63 pmol). These results demonstrated that CRF injected in a picomole amount into the cerebrospinal fluid acts within the brain to inhibit gastric emptying of a liquid meal through vagal-dependent pathways.