LANDMARK STABILITY IS A PREREQUISITE FOR SPATIAL BUT NOT DISCRIMINATION-LEARNING
LANDMARK STABILITY IS A PREREQUISITE FOR SPATIAL BUT NOT DISCRIMINATION-LEARNING
复制标题
DOI：
10.1038/361631a0
复制
发表时间：
1993-02-18
期刊：
影响因子：
64.8
通讯作者：
MORRIS, RGM
中科院分区：
文献类型：
--
作者：
BIEGLER, R;MORRIS, RGM
来自海马结构不同区域的神经元对位置和方向敏感1,2，空间学习和海马结构之间的异速关系3,4以及该区域损伤后空间学习的明显损伤5-8，表明海马结构促进异中心空间学习9,10。为了更多地了解空间表示的过程，我们开发了一项任务，可以提供对地标和方向线索的独立控制。在生理11和行为12工作的基础上，该任务还可以研究联想学习原理（例如可预测性13）与空间域的相关性。我们在这里报告，尽管老鼠学会根据地标与可靠预测的食物奖励的接近程度来区分地标，但只有在几何参考系内保持稳定的位置时，它们才会学会使用它们来表示其位置。
NEURONS sensitive to both place and direction from distinct regions of the hippocampal formation1,2, allometric relationships between spatial learning and hippocampal structure3,4 and pronounced impairments in spatial learning after lesions in this area5-8, indicate that the hippocampal formation subserves allocentric spatial learning9,10. To learn more about the process of spatial representation, we have developed a task that provides independent control of both landmark and directional cues. On the basis of physiological11 and behavioural12 work, this task also makes it possible to investigate the relevance of associative learning principles, such as predictability13, to the spatial domain. We report here that although rats learn to discriminate between landmarks on the basis of their proximity to a reliably predicted food reward, they will only learn to use them to represent its location if they maintain stable locations within a geometric frame of reference.