Many children aged two to five years have a persistent presence of respiratory viruses in their nasopharynx
Many children aged two to five years have a persistent presence of respiratory viruses in their nasopharynx
复制标题
DOI：
10.1111/apa.13259
复制
发表时间：
2016-02-01
期刊：
影响因子：
3.8
通讯作者：
Priftis, Kostas N.
中科院分区：
文献类型：
--
作者：
Douros, Konstantinos;Kotzia, Doxa;Priftis, Kostas N.
幼儿平均每年有6至8次病毒性呼吸道感染（VRI）(1)。这种高流行率，加上易于在社区传播，使VRI成为儿童门诊和住院的最常见原因。这也是孩子旷课和父母旷工照顾他们的主要原因之一。呼吸道合胞病毒（RSV）、副流感病毒、流感病毒和腺病毒在引起婴幼儿急性呼吸道感染（ARI）中的作用已得到充分证实(1)。其他一些病毒在儿童呼吸道疾病发展中的重要性最近才得到澄清。鼻病毒和冠状病毒（通常被称为普通感冒病原体）除了作为上呼吸道病原体的已知作用外，已被证明可引起下呼吸道疾病（3,4），而偏肺病毒(5)和人博卡病毒(6)已被确定为呼吸道急性疾病病原体。然而，大多数关于VRI的研究采用横断面设计，并侧重于特定病毒与一系列症状发展的关系。相对较少的研究涉及特定病毒在呼吸道中长期存在而不引起症状或多种病毒共存的潜在影响（7-10）。在本研究中，我们旨在前瞻性地描述生活在城市或农村地区的无症状学龄前儿童上呼吸道中呼吸道病毒的存在模式。
On average, young children have six to eight viral respiratory infections (VRI) per year (1). This high prevalence, combined with the ease of spread in the community, makes VRI the most common reason for outpatient visits and hospitalisation in childhood. It is also one of the main reasons that children miss school and their parents miss work to care for them (2). The role of respiratory syncytial viruses (RSV), the parainfluenza virus, influenza virus and adenovirus in causing acute respiratory infections (ARI) in infants and children is well established (1). The importance of some other viruses in the development of respiratory illnesses in children has been clarified relatively recently. In addition to their known role as upper respiratory tract pathogens, rhinoviruses and coronaviruses, often referred to as common cold agents, have been shown to cause lower respiratory tract disease (3, 4), whereas the metapneumovirus (5) and human bocavirus (6) have been identified as acute disease causing agents of the respiratory tract. However, the majority of studies on VRI utilise a crosssectional design and focus on the relation of a particular virus to the development of a constellation of symptoms. Relatively few studies have dealt with the potential impact of the prolonged presence of a particular virus in the respiratory tract without giving rise to symptoms or with the coexistence of more than one virus (7–10). In the present study, we aimed to prospectively describe the pattern of the presence of respiratory viruses in the upper airways of asymptomatic preschool-aged children living in either urban or rural areas.