Mitogen-activated protein kinase cascades as regulators of stress responses
Mitogen-activated protein kinase cascades as regulators of stress responses
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DOI：
10.1111/j.1749-6632.1998.tb08987.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Karin, M
中科院分区：
文献类型：
--
作者：
Karin, M
丝裂原激活蛋白激酶 (MAPK) 级联凭借其磷酸化和调节各种转录因子活性的能力，在将环境刺激转导至细胞核转录机制中发挥着重要作用。 MAPK 级联最初被发现是响应细胞表面多肽激素、细胞因子和生长因子受体的占据而被激活的，最近发现 MAPK 级联被多种应激激活，包括缺血再灌注、神经元损伤、渗透性休克和暴露于紫外线照射。因此，MAPK级联很可能是多种应激反应中的重要调节元件。
Mitogen-activated protein kinase (MAPK) cascades play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. Originally found to be activated in response to occupancy of cell surface receptors for polypeptide hormones, cytokines, and growth factors, MAPK cascades were recently found to be activated by a variety of stresses including ischemia reperfusion, neuronal injury, osmotic shock, and exposure to UV irradiation. Therefore, MAPK cascades are likely to be important regulatory elements in a variety of stress responses.