NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice
NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice
复制标题
脑心通胶囊抑制角叉菜胶诱导的小鼠血栓形成
DOI：
10.1097/fjc.0000000000000592
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发表时间：
2018-07-01
影响因子：
3
通讯作者：
Yang, Xiaoxiao
中科院分区：
文献类型：
--
作者：
Li, Qi;Chen, Yi;Yang, Xiaoxiao
Abstract: Formation of thrombosis is mainly associated with dysfunctions of endothelial cells. NaoXinTong capsule (NXT), a traditional Chinese medicine, has been demonstrated multiple protective effects on vascular systems. However, it is unknown the effect of NXT on thrombosis. In this study, we determined whether NXT can inhibit carrageenan-induced thrombosis and the underlying mechanisms. Two days after carrageenan injection, severe thrombi were found in blood vessels of mouse tail and liver. By contrast, thrombi were substantially reduced by NXT treatment, and the reduction was associated with reduced serum tumor necrosis factor &agr; and P-selectin levels. In vitro, NXT reduced lipopolysaccharide-activated adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) by inhibiting expression of adhesion molecules and interleukin 6, and reducing production of mitochondrial superoxide that is related to activation of antioxidant enzymes expression. NXT also reduced oxidized low-density lipoprotein-activated adhesion of platelets to HUVECs. In addition, NXT protected HUVECs against clopidogrel-induced cell death by inhibiting expression of tumor necrosis factor–like cytokine 1A and activating expression of vascular endothelial growth factor &agr;. Taken together, our study indicates the potential application of NXT in antithrombosis by multiple antithrombotic functions.
