Synthesis of 3-Formylindoles via Electrochemical Decarboxylation of Glyoxylic Acid with an Amine as a Dual Function Organocatalyst
Synthesis of 3-Formylindoles via Electrochemical Decarboxylation of Glyoxylic Acid with an Amine as a Dual Function Organocatalyst
复制标题
胺作为双功能有机催化剂，乙醛酸电化学脱羧合成 3-甲酰基吲哚
DOI：
10.1021/acs.orglett.9b01971
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Huang Jing Mei
中科院分区：
文献类型：
--
作者：
Lin Dian Zhao;Huang Jing Mei
以乙醛酸为原料，胺为双功能有机催化剂，研究了吲哚类化合物的电化学脱羧反应。胺的负载量可低至1mol%，有效地促进了电化学脱羧和亲核反应。该方案在环境条件下具有广泛的官能团耐受性。克级实验表明，该策略的综合应用具有很大的潜力。
A new method for 3-formalytion of indoles has been developed through electrochemical decarboxylation of glyoxylic acid with the amine as a dual function organocatalyst. The amine facilitated both the electrochemical decarboxylation and the nucleophilic reaction efficiently, whose loading can be as low as 1 mol %. This protocol has a broad range of functional group tolerance under ambient conditions. The gram-scale experiment has shown great potential in the synthetic application of this strategy.