Molecular determinants regulating the release of the egg during ovulation: Perspectives in piscine models
Molecular determinants regulating the release of the egg during ovulation: Perspectives in piscine models
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DOI：
10.1016/j.aaf.2022.03.009
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发表时间：
2022-09-01
影响因子：
--
通讯作者：
Maitra, Sudipta
中科院分区：
文献类型：
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作者：
Ghosh, Soumyajyoti;Biswas, Subhasri;Maitra, Sudipta
硬骨鱼，特别是雌性硬骨鱼的繁殖，包含明确的阶段，包括生长和发育、最终卵母细胞成熟和最终排卵？？？形成可受精雌配子的先决条件。排卵反应期间遇到的形态变化涉及多种内分泌、自分泌和旁分泌因素。这些包括性腺类固醇、生长因子、炎症细胞因子、前列腺素、白三烯和基质金属蛋白酶。近年来，前列腺素及其受体在LH依赖性排卵作用中的积极参与备受关注。大量证据还支持一氧化氮/一氧化氮合酶（NO/NOS）单位参与调节减数分裂成熟和排卵级联。然而，关于这些候选分子触发鱼卵巢排卵的生理相关性、相互关系和共同努力的信息相对较少。本文的主要目的是总结卵泡层 LH 作用下游主要候选分子之间的潜在交叉。此外，前列腺素 (PG) 相对于 NO/NOS 系统对哺乳动物和硬骨鱼排卵反应的卵巢内作用也得到了强调。
Reproduction in bony fish, specifically in the female teleost, encompasses well-defined stages, including growth and development, final oocyte maturation and finally ovulation ??? a pre-requisite for forming fertilizable female gametes. The morphological changes encountered during ovulatory response engage a multitude of endocrine, autocrine, and paracrine factors. These include gonadal steroids, growth factors, inflammatory cytokines, prostaglandins, leukotrienes and matrix metalloproteinases. In recent years, the active participation of prostaglandins and their receptors in LH-dependent ovulatory action has received much attention. Considerable evidence also supports the participation of nitric oxide/nitric oxide synthase (NO/NOS) unit in regulating meiotic maturation and ovulatory cascade. However, relatively less information is available on physiological relevance, the inter-relationship and the conjoined efforts of these molecular candidates to trigger ovulation in the fish ovary. The prime objective of the present article is to summarize the potential cross-talk between major molecular candidates downstream of LH action in the follicular layer. Besides, the intraovarian role of prostaglandin (PG) vis-`a-vis NO/NOS system on mammalian and teleost ovulatory response has been emphasised.