Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: Its association with disease progression and survival
Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: Its association with disease progression and survival
复制标题
DOI：
10.1158/1078-0432.ccr-07-4144
复制
发表时间：
2008-04-15
影响因子：
11.5
通讯作者：
Kikkawa, Fumitaka
中科院分区：
文献类型：
--
作者：
Ino, Kazuhiko;Yamamoto, Eiko;Kikkawa, Fumitaka
目的：肿瘤逃离宿主免疫系统是疾病进展的重要机制。我们最近发现免疫抑制酶吲哚胺2,3-双加氧酶（IDO）是子宫内膜癌的预后指标。本研究的目的是探讨IDO表达与肿瘤浸润淋巴细胞（TIL）或自然杀伤细胞（NK）的关系，并阐明其在子宫内膜癌中的预后作用。实验设计：采用免疫组化染色法检测65例子宫内膜癌组织IDO表达。连续组织切片计数肿瘤浸润性CD3+、CD8+淋巴细胞及CD57+ NK细胞。结果：65例患者中有32例肿瘤细胞IDO高表达，IDO高表达与肌层浸润、淋巴结转移、淋巴管间隙受累呈正相关。我们还发现高IDO表达与CD3+、CD8+和CD57+细胞浸润肿瘤上皮和间质数量减少之间存在显著相关性。IDO高表达的患者，间质CD3 (
Purpose: Tumor escape from host immune systems is a crucial mechanism for disease progression. We recently showed that the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is a prognostic indicator for endometrial cancer. The purpose of the present study was to investigate the relationship between IDO expression and tumor-infiltrating lymphocytes (TIL) or natural killer (NK) cells and to clarify their prognostic effect in endometrial cancer.Experimental Design: Immunohistochemical staining for IDO expression in endometrial cancer tissues (n = 65) was done. Tumor-infiltrating CD3+ and CD8+ lymphocytes, as well as CD57+ NK cells, were counted in serial tissue sections.Results: High IDO expression in tumor cells was found in 32 of 65 cases and was positively correlated with myometrial invasion, nodal metastasis, and lymph-vascular space involvement. We also found a significant correlation between high IDO expression and reduced numbers of CD3+, CD8+, and CD57+ cells infiltrating into both the tumor epithelium and stroma. Patients with high IDO expression, a low number of stromal CD3 (