The interleukin-4 -589C/T polymorphism and the risk of asthma: a meta-analysis including 7,345 cases and 7,819 controls.
The interleukin-4 -589C/T polymorphism and the risk of asthma: a meta-analysis including 7,345 cases and 7,819 controls.
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DOI：
10.1016/j.gene.2013.02.027
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发表时间：
2013-05
期刊：
影响因子：
3.5
通讯作者：
W. Nie;Zhaoqin Zhu;Xin-min Pan;Q. Xiu
中科院分区：
文献类型：
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作者：
W. Nie;Zhaoqin Zhu;Xin-min Pan;Q. Xiu
GROUNDA研究评估了白细胞介素-4（IL-4）启动子区− 589 C/T多态性与不同人群哮喘的相关性。然而，结果是矛盾的。方法检索Pubmed、EMBASE、万方数据库、中国知网（CNKI）、维普数据库等相关数据库，并进行Meta分析，探讨IL-4基因多态性与哮喘易感性的关系。采用比值比（OR）和95%置信区间（CI）评估相关性的强度。总体而言，TT+CT与CC相比，− 589 C/T多态性与哮喘显著相关（OR=1.26; 95%CI 1.12-1.42; P=0.0001; I2=26%）。在按种族进行的亚组分析中，发现亚洲人与此有显著关联（OR=1.36; 95% CI 1.07-1.73; P=0.01; I2=0%）和白人（OR=1.30; 95% CI 1.09-1.54; P=0.004; I2=53%），但非裔美国人中没有（OR=1.20; 95% CI 0.72-2.00; P=0.48; I2=48%）。在特应性状态的亚组分析中，在特应性哮喘患者中没有发现显著的相关性（OR=1.20; 95%CI 0.92-1.34; P=0.27; I2=6%）和非特应性哮喘患者OR=0.97; 95%CI 0.73-1.28; P=0.81; I2=0%）。结论IL-4 − 589 C/T多态性是哮喘的危险因素。
BACKGROUNDA number of studies assessed the association of −589C/T polymorphism in the promoter region of interleukin-4 (IL-4) with asthma in different populations. However, the results were contradictory. A meta-analysis was conducted to investigate the association between polymorphism in the IL-4 and asthma susceptibility.METHODSDatabases including Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.RESULTSThirty-four studies involving 7345 cases and 7819 controls were included. Overall, significant association between −589C/T polymorphism and asthma was observed for TT+CT vs. CC (OR=1.26; 95% CI 1.12–1.42; P=0.0001; I2=26%). In the subgroup analysis by ethnicity, significant associations were found among Asians (OR=1.36; 95% CI 1.07–1.73; P=0.01; I2=0%) and Caucasians (OR=1.30; 95% CI 1.09–1.54; P=0.004; I2=53%) but not among African Americans (OR=1.20; 95% CI 0.72–2.00; P=0.48; I2=48%). In the subgroup analysis by atopic status, no significant association was found among atopic asthma patients (OR=1.20; 95% CI 0.92–1.34; P=0.27; I2=6%) and non-atopic asthma patients (OR=0.97; 95% CI 0.73–1.28; P=0.81; I2=0%).CONCLUSIONSThis meta-analysis suggested that the IL-4 −589C/T polymorphism was a risk factor of asthma.