Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction
Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction
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DOI：
10.1007/s10753-007-9025-3
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发表时间：
2007-08-01
期刊：
影响因子：
5.1
通讯作者：
Hu, Ming-yan
中科院分区：
文献类型：
--
作者：
Guo, Jun;Lin, Guo-sheng;Hu, Ming-yan
本研究的目的是研究在心肌梗塞大鼠模型中抗炎对MSC移植的作用。左冠状动脉的阻塞引起的AMI大鼠被随机分为MSC移植组，MI组和假手术组。在MI 4周后，观察到MSC移植对非尖端区域中心脏炎症和左心室重塑的影响。我们发现MSC移植（1）降低了蛋白质的产生和炎症细胞因子TNF-Alpha，IL-1β和IL-6，（2）抑制I型和III胶原蛋白的沉积，以及基因和蛋白质表达的抑制沉积。 MMP-1和TIMP-1，（3）减弱LV的腔腔扩张和透壁梗塞变薄，从而防止心肌重塑后心肌梗塞，（4）增加EF，FS，LVESP和DP/DTMAX（P <0.01），LVDD，LVEDV，LVEDV，LVEDP降低（P <0.05）。 MSC移植的抗炎作用可能部分解释了缺血性心脏病的心脏保护作用。
The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-alpha, IL-1 beta and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.