The solubility parameter as a tool in understanding liquid chromatography
The solubility parameter as a tool in understanding liquid chromatography
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溶解度参数作为理解液相色谱的工具
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
L. Galan
中科院分区：
文献类型：
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作者：
P. Schoenmakers;H. Billiet;L. Galan
简要讨论了溶度参数的概念。然后，它被用来解释一些目前的特点，液体分配和吸附色谱。根据保留、选择性（系统的一般分离能力）和特异性（对某些溶质对增加分离能力）这三个特征讨论了各种相系统。出现了两种本质上不同的技术，“正常相位”和“反相位”模式，将出现作为简化理论的逻辑结果。这也是为什么“反相”应用如此之多的原因。对开发新的固定相和改进现有的固定相提出了建议。溶解度参数的概念，以预测反相液相色谱（RPLC）中的混合洗脱液的溶剂强度的实用性进行了论证。制定了固定和移动的相位系统的选择和操作的一些实用规则。
SummaryThe solubility parameter concept is briefly discussed. It is then used to explain some of the current features of liquid partition and adsorption chromatography. Various phase systems are discussed on the basis of three characteristics.retention, selectivity (the general separation power of a system) andspecificity (increased separation power towards certain pairs of solutes). The emergence of two essentially different techniques, the ‘normal phase’ and ‘reversed phase’ modes, will appear as a logical consequence of simplified theory. It also becomes obvious why ‘reversed phase’ applications are so much more numerous. Some suggestions are given for the development of new stationary phases and the improvement of existing ones. The usefulness of the solubility parameter concept to predict the solvent strength of mixed eluents in reversed phase liquid chromatography (RPLC) is demonstrated. Some practical rules for the selection and operation of stationary and mobile phase systems are formulated.