Calculation of the outcomes of remodeling of arteries subjected to sustained hypertension using a 3D two-layered model.
Calculation of the outcomes of remodeling of arteries subjected to sustained hypertension using a 3D two-layered model.
复制标题
使用 3D 两层模型计算持续高血压下动脉重塑的结果。
DOI：
10.1007/s10439-012-0727-9
复制
发表时间：
2013
影响因子：
3.8
通讯作者：
Vito,RaymondP
中科院分区：
文献类型：
--
作者：
Rachev,Alexander;Taylor,WRobert;Vito,RaymondP
动脉表现出对动脉压和血流的长期改变的重塑响应，其通过由血管壁中的局部应力从其基线值的扰动驱动的过程来改变几何形状、结构和组成。本研究的目的是双重的开发一个通用的方法来计算的动脉被认为是一个双层管的重塑反应，并提供结果的冠状动脉的适应性和适应不良的重塑。通过制定血管力学的逆问题，动脉的几何尺寸和机械性能计算从规定的变形配置，应力场，结构刚度，和施加的负载。作为一个说明性的例子，我们认为一个人的LAD冠状动脉在一个完美的和不完全的适应性反应，持续的逐步变化的压力和适应不良的反应，由于受损的外膜重塑。结果表明，当动脉承受高动脉压时，外膜在血管力学中起着重要作用。除了其众所周知的防止动脉过度膨胀的短期功能之外，似乎可以合理地接受外膜响应于压力慢性增加而重塑的方式对于保持正常动脉功能是必不可少的，或者可能导致发生血管疾病的风险增加。
Arteries manifest a remodeling response to long-term alterations in arterial pressure and blood flow by changing geometry, structure, and composition through processes driven by perturbations of the local stresses in the vascular wall from their baseline values. The objective of this study is twofold—to develop a general method for calculating the remodeling responses of an artery considered as a two-layered tube; and to provide results for adaptive and maladaptive remodeling of a coronary artery. By formulating an inverse problem of vascular mechanics, the geometrical dimensions and mechanical properties of an artery are calculated from a prescribed deformed configuration, stress field, structural stiffness, and applied load. As an illustrative example we consider a human LAD coronary artery in both a perfect and incomplete adaptive response to a sustained step-wise change in pressure and a maladaptive response due to impaired remodeling of adventitia. The results obtained show that adventitia plays an important role in vascular mechanics when an artery is subjected to high arterial pressure. In addition to its well-known short term function of preventing over-inflation of an artery, it seems reasonable to accept that the manner by which adventitia remodels in response to a chronic increase in pressure is essential for preserving normal arterial function or may lead to an increased risk of developing vascular disorders.