The transfer of 2,4,5,2',4',5'-hexachlorobiphenyl to fetuses and nursing offspring. II. Induction of hepatic microsomal monooxygenase activity in pregnant and lactating mice and their young.
The transfer of 2,4,5,2',4',5'-hexachlorobiphenyl to fetuses and nursing offspring. II. Induction of hepatic microsomal monooxygenase activity in pregnant and lactating mice and their young.
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2,4,5,2,4,5-六氯联苯向胎儿和哺乳后代的转移。
DOI：
10.1016/0041-008x(80)90200-8
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发表时间：
1980
影响因子：
3.8
通讯作者：
Lech,JJ
中科院分区：
文献类型：
--
作者：
Vodicnik,MJ;Elcombe,CR;Lech,JJ
本文研究了2，4，5，2‘，4’，5‘-六氯联苯(6-CB)对处女鼠、孕鼠和哺乳期小鼠及其子代肝微粒体单加氧酶活性的影响。交配前14天单次注射6-CB 100 mg/kg。在怀孕前和怀孕早期，所有6-CB处理组小鼠的肝脏单加氧酶活性均高于玉米油对照组。在两组怀孕和处女动物之间都没有观察到显著的差异。在妊娠中后期和哺乳期早期，玉米油处理组母鼠的细胞色素P-450含量低于同期处女，哺乳期动物苯丙胺-N-脱甲基和乙氧基香豆素-O-脱甲基也减少。经6-CB处理并于出生当天处死的母鼠的微粒体单加氧酶活性和细胞色素P-450含量低于同时处死的6-CB处理的处女，但在哺乳期这两组动物之间没有差异。肝脏酶活性和细胞色素P-450含量在用玉米油和6-CB处理的新生儿(出生第1天)之间没有差别。然而，与玉米油处理的母亲相比，6-CB处理的母亲产后5到20天的哺乳后代的这些参数升高，这表明通过母乳转移的6-CB的数量足以影响肝脏微粒体单加氧酶的活性。
The effect of 2,4,5,2′,4′,5′-hexachlorobiphenyl (6-CB) on hepatic microsomal monooxygenase activity in virgin or pregnant and lactating mice and their offspring was examined. 6-CB was administered in a single dose of 100 mg/kg 14 days before mating. Prior to, and during early pregnancy, hepatic monooxygenase activity in all 6-CB-pretreated mice was greater than that in corn oil controls. No notable differences were observed between pregnant and virgin animals in either group. Corn oil-pretreated mothers had lower cytochrome P-450 content during mid to late pregnancy and early lactation than that observed in virgins sacrificed at the same time, and benzphetamine-N-demethylation and ethoxycoumarin-O-deethylation were also decreased in lactating animals. Mothers pretreated with 6-CB and sacrificed on the day of birth had lower microsomal monooxygenase activity and cytochrome P-450 content than 6-CB-pretreated virgins sacrificed concurrently, but no differences were noted between these groups of animals during lactation. Hepatic enzyme activities and cytochrome P-450 content were not different between newborns (Day 1) of corn oil- and 6-CB-pretreated mothers. However, these parameters were elevated in 5- to 20-day postpartum nursing offspring from 6-CB-pretreated mothers when compared to those from corn oil-pretreated mothers suggesting transfer of 6-CB through breast milk in quantities sufficient to affect hepatic microsomal monooxygenase activity.