Early detection of age-related memory deficits in individual mice
Early detection of age-related memory deficits in individual mice
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DOI：
10.1016/j.neurobiolaging.2009.11.001
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发表时间：
2011-10-01
影响因子：
4.2
通讯作者：
Rondi-Reig, L.
中科院分区：
文献类型：
--
作者：
Fouquet, C.;Petit, G. H.;Rondi-Reig, L.
迄今为止，尚未达成共识，关于年龄相关的认知缺陷的啮齿动物的最早发病年龄。我们的目标是开发一种行为模型，允许早期和个体检测与年龄相关的认知障碍。我们在星迷宫中测试了年轻（3个月），中年（10个月）和老年（17个月）的C57B116小鼠，该任务允许通过标准化计算两个导航指数来精确分析小鼠的搜索模式。我们对每只小鼠进行了分析，并将每只小鼠的表现与基于年轻小鼠表现的阈值进行了比较。使用这种方法，我们从10个月大的年龄识别受损的小鼠。他们的赤字是独立的任何感觉运动功能障碍，并与海马CA1晚LTP的维护的改变。这项研究为早期发现与年龄相关的记忆障碍开发了可靠的方法，并提供了证据表明，一些人早在10个月大的时候记忆就会下降。(C)2009 Elsevier Inc. All rights reserved.
To date, no consensus has been reached concerning the age of the earliest onset of age-related cognitive deficits in rodents. Our aim was to develop a behavioral model allowing early and individual detection of age-related cognitive impairments. We tested young (3 months), middle-aged (10 months) and aged (17 months) C57B116 mice in the starmaze, a task allowing precise analysis of the search pattern of mice via standardized calculation of two navigation indices. We performed mouse-per-mouse analyses and compared each mouse's performance to a threshold based on young mice's performances. Using this method we identified impaired mice from the age of 10 months old. Their deficits were independent of any sensorimotor dysfunctions and were associated with an alteration of the maintenance of the hippocampal CA1 late-LTP. This study develops reliable methodology for early detection of age-related memory disorders and provides evidence that memory can decline in some individuals as early as from the age of 10 months. (C) 2009 Elsevier Inc. All rights reserved.