Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
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DOI：
10.1016/j.ygeno.2010.07.006
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发表时间：
2010-10
期刊：
影响因子：
4.4
通讯作者：
Bowden, Donald W.
中科院分区：
文献类型：
--
作者：
Lewis, Joshua P.;Palmer, Nicholette D.;Ellington, Jennifer B.;Divers, Jasmin;Ng, Maggie C. Y.;Lu, Lingyi;Langefeld, Carl D.;Freedman, Barry I.;Bowden, Donald W.
在多个人群中，染色体20 q12-q13.1与2型糖尿病（T2 D）有关。我们在两个欧洲裔美国人病例对照人群中研究了该区域基因对T2 D和BMI的影响。在300例糖尿病患者和310例对照中进行SNPs基因分型。在470例病例和442例对照中进一步对72个SNP的子集进行基因分型。在初始样品中，检查的所有基因均显示出与T2 D相关的证据（加性P值[Pa] =0.00090-0.045）。在第二个病例对照人群中，PREX 1附近的SNP也相关（Pa=0.017-0.042）。组合分析产生了与T2 D相关的相同SNP等（Pa=0.0013-0.041）。按T2 D状态进行的分层分析显示，仅在病例中观察到与BMI的相关性（Pa=0.0018-0.041）。中介测试显示，这些SNP对T2 D的影响中有30-40%是由BMI显著介导的。PREX 1附近的SNP可能通过肥胖的影响介导了欧洲裔美国人的T2 D易感性
Chromosome 20q12-q13.1 has been linked to type 2 diabetes (T2D) in multiple populations. We examined the influence of genes in this region on T2D and BMI in two European American case-control populations. SNPs were genotyped in 300 diabetic patients and 310 controls. A subset of 72 SNPs were further genotyped in 470 cases and 442 controls. All genes examined showed evidence of association with T2D in the initial sample (additive P-value [Pa] =0.00090–0.045). SNPs near PREX1 were also associated in the second case-control population (Pa=0.017–0.042). The combined analysis resulted in the same SNPs, among others, associated with T2D (Pa=0.0013–0.041). Stratification analysis by T2D status showed that association with BMI was observed solely in cases (Pa=0.0018–0.041). Mediation testing revealed 30–40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
7.7
作者：
Mori, Y;Otabe, S;Froguel, P
通讯作者：
Froguel, P
DOI：
10.1073/pnas.021506298
发表时间：
2001-01-16
影响因子：
11.1
作者：
Buetow, KH;Edmonson, M;Braun, A
通讯作者：
Braun, A
影响因子：
48
作者：
Matarin, Mar;Brown, W. Mark;Meschia, James F.
通讯作者：
Meschia, James F.
影响因子：
3.7
作者：
GOODMAN, LA
通讯作者：
GOODMAN, LA