The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis.
The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis.
复制标题
手术干预在原发性结直肠淋巴瘤中的作用：基于 SEER 人群的分析
DOI：
10.18632/oncotarget.12344
复制
发表时间：
2016-11-01
期刊：
影响因子：
--
通讯作者：
Ding KF
中科院分区：
文献类型：
--
作者：
Cai YB;Chen HY;He JJ;Hu YT;Yang Q;Chen LB;Xiao Q;Ding KF
背景原发性结直肠淋巴瘤是一种罕见的结直肠恶性肿瘤。PCL的标准治疗和预后因素尚未探讨。因此，应该进行一项大规模的基于人群的研究，以提供对这种疾病的详细审查。方法提取1973 - 2011年SEER数据库中登记的符合条件的PCL患者数据。所有统计分析均使用SPSS 19.0进行。结果3342例PCL患者中，2050例（61.3%）接受了手术治疗，1292例（38.7%）未接受手术治疗。中位总生存期为95个月，接受手术的患者生存期显著延长（校正HR =0.69，P <0.001）。年轻、早期肿瘤分期和惰性淋巴瘤是提高生存率的独立预测因素。进一步的生存分析表明，手术在早期肿瘤、右侧病变或弥漫性大B细胞PCL患者中具有潜在获益。相反，手术干预并没有改善晚期、左侧或惰性PCL患者的生存率。结论后交叉韧带是一种少见的肿瘤，治疗效果良好。手术治疗在PCL的治疗中可能发挥重要作用。早期肿瘤阶段、右侧病变和弥漫性大B细胞组织学PCL似乎是最佳手术候选人的临床特征。
Background Primary colorectal lymphoma (PCL) is a rare colorectal malignancy. The standard treatment and prognostic factors of PCL remain unexplored. Therefore, a large population-based study should be conducted to provide a detailed review of this disease. Methods We extracted the data of eligible patients with PCL registered in the SEER database from 1973 to 2011. All statistical analyses were performed using SPSS 19.0. Results A total of 2050 (61.3%) of the 3342 patients with PCL underwent surgical intervention, and 1292 (38.7%) patients received no surgical treatment. The median overall survival was 95 months, and patients receiving surgery exhibited significantly prolonged survival (adjusted HR =0.69, P <0.001). Young age, early tumor stage, and indolent lymphoma were independent predictors of improved survival. Further survival analyses demonstrated the potential benefit of surgery in patients with early tumor stage, right-sided lesions, or diffuse large B-cell PCL. Conversely, surgical intervention did not improve the survival of patients with advanced-stage, left-sided, or indolent PCL. Conclusion PCL is a rare tumor that can be effectively treated. Surgical intervention may play an important role in the treatment of PCL. Early tumor stage, a right-sided lesion, and diffuse large B-cell histological PCL seem to be the clinical characteristics of optimal surgical candidates.