Two Distinct Channels of Olfactory Bulb Output
Two Distinct Channels of Olfactory Bulb Output
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DOI：
10.1016/j.neuron.2012.05.017
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发表时间：
2012-07-26
期刊：
影响因子：
16.2
通讯作者：
Schaefer, Andreas T.
中科院分区：
文献类型：
--
作者：
Fukunaga, Izumi;Berning, Manuel;Schaefer, Andreas T.
节律性神经活动是大脑功能的一个标志，被广泛用于构建神经信息。在哺乳动物的嗅觉中，重复性的嗅吸设定了主要的节律，但人们对其在感觉编码中的作用知之甚少。在此，我们表明，嗅球投射神经元的两个主要类别—— mitral细胞和tufted细胞，紧密地锁定于这一节律，但处于嗅吸周期的相反相位。这种相位偏移是由局部抑制所建立的，这种抑制选择性地延迟mitral细胞的活动。此外，尽管tufted细胞的相位在对纯兴奋性气味物质的反应中不受干扰，但mitral细胞的相位以一种分级的、依赖刺激的方式提前。因此，通过抑制实现的相位分离构成了两种不同的嗅觉处理通道的基础。
Rhythmic neural activity is a hallmark of brain function, used ubiquitously to structure neural information. In mammalian olfaction, repetitive sniffing sets the principal rhythm but little is known about its role in sensory coding. Here, we show that mitral and tufted cells, the two main classes of olfactory bulb projection neurons, tightly lock to this rhythm, but to opposing phases of the sniff cycle. This phase shift is established by local inhibition that selectively delays mitral cell activity. Furthermore, while tufted cell phase is unperturbed in response to purely excitatory odorants, mitral cell phase is advanced in a graded, stimulus-dependent manner. Thus, phase separation by inhibition forms the basis for two distinct channels of olfactory processing.