A comparison of the electrical characteristics, liquid composition, and toxicant emissions of JUUL USA and JUUL UK e-cigarettes
A comparison of the electrical characteristics, liquid composition, and toxicant emissions of JUUL USA and JUUL UK e-cigarettes
复制标题
DOI：
10.1038/s41598-020-64414-5
复制
发表时间：
2020-04-30
影响因子：
4.6
通讯作者：
Shihadeh, Alan
中科院分区：
文献类型：
--
作者：
Talih, Soha;Salman, Rola;Shihadeh, Alan
2018年，Juul进入英国市场，欧盟法规将液体尼古丁浓度限制在20毫克/毫升，约为Juul产品在美国销售水平的三分之一。我们假设Juul的英国产品是为了提供更大的电力并促进液体汽化而设计的，因此净尼古丁传送率与美国版本相似。我们比较了在美国和英国采购的JUUL设备的电气特性、液体成分和气溶胶排放。研究结果包括电力、总尼古丁和游离基尼古丁、丙二醇甘油/植物甘油比率、羰基和活性氧物种。液体和气溶胶用气相色谱、高效液相色谱和荧光光谱分析。与美国版本相比，Juul UK的液体尼古丁浓度约为液体尼古丁浓度的三分之一(5.4wt.%比1.6wt.%)和气雾剂(4.7wt.%和1.3wt.%)。除了尼古丁浓度和产量外，我们发现任何其他研究结果都没有差异，包括电力。目前，Juul UK的尼古丁排放量远远低于美国产品，这为研究这一因素如何影响两个市场的用户行为、Juul摄入量和其他人群水平的结果提供了机会。
In 2018, JUUL entered the UK market, where EU regulations limit liquid nicotine concentration to 20mg/mL, approximately one-third the level of JUUL products sold in the USA. We hypothesized that JUUL's UK product was engineered to deliver greater electrical power and boost liquid vaporization such that the net nicotine delivery rate was similar to the US version. We compared electrical characteristics, liquid composition, and aerosol emissions of JUUL devices procured in the USA and the UK. Study outcomes included electrical power, total and freebase nicotine, propylene glycol/vegetable glycerin ratio, carbonyls, and reactive oxygen species. Liquids and aerosols were analyzed by GCMS, HPLC, and fluorescence. Compared to the US version, JUUL UK had approximately one-third the liquid nicotine concentration in the liquid (5.4 vs. 1.6 wt.%) and aerosol (4.7 and 1.3 wt.%). Other than nicotine concentration and yield, we found no differences in any other study outcome, including electrical power. Currently, JUUL UK emits nicotine at a far lower rate than the US product, offering an opportunity to study how this factor impacts user behavior, JUUL uptake, and other population-level outcomes across the two markets.