Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors
Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors
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DOI：
10.1016/j.numecd.2009.08.014
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发表时间：
2011-03-01
影响因子：
3.9
通讯作者：
Mikhailidis, D. P.
中科院分区：
文献类型：
--
作者：
Athyros, V. G.;Kakafika, A. I.;Mikhailidis, D. P.
背景和目的：地中海饮食与降低心血管疾病（CVD）风险有关。使用植物甾烷醇降低低密度脂蛋白胆固醇（LDL-C）浓度。我们比较了地中海饮食和植物甾烷醇酯对血管危险因素和估计心血管疾病（eCVD）risk.Methods和results的影响：在这项前瞻性，随机，安慰剂对照研究中，150轻度高胆固醇血症的受试者被随机分配到地中海饮食，传播含有植物甾烷醇酯（2克/天）或安慰剂传播。每月评估血管风险因素，持续4个月，并使用前瞻性血管-Munster（PROCAM）、Fragrance和Reynolds风险引擎计算eCVD风险。安慰剂对风险因素或eCVD风险无显著影响。地中海饮食逐渐诱导总胆固醇（TC）、LDL-C、甘油三酯、高敏C反应蛋白（hsCRP）、血压和eCVD风险（24-32%）显著降低。植物甾烷醇酯扩散降低（1个月）TC（-14%），LDL-C（-16%），hsCRP（-17%）和估计的CVD风险（26-30%）。eCVD风险降低持续在第4个月时，逐渐地中海饮食eCVD风险降低变得可比的stanol group.Conclusions：植物甾烷醇酯产生了早期，由第1个治疗月，降低eCVD风险，导致TC，LDL-C和hsCRP降低。地中海饮食的eCVD风险降低是由于几种CVD风险因素的变化，并且在4个月时与植物甾烷醇相当。中度高胆固醇血症患者食用植物甾烷醇酯可能是一种有用的选择，可以降低那些不采用地中海饮食的人的CVD风险。(C)2009 Elsevier B. V.保留所有权利。
Background and aims: Mediterranean diet is associated with a reduced risk for cardiovascular disease (CVD). Use of plant stanols decreases low density lipoprotein cholesterol (LDL-C) concentrations. We compared the effects of the Mediterranean diet and plant stanol esters on vascular risk factors and estimated CVD (eCVD) risk.Methods and results: In this prospective, randomized, placebo-controlled study, 150 mildly hypercholesterolaemic subjects were randomized to Mediterranean diet, a spread containing plant stanol esters (2 g/day) or a placebo spread. Vascular risk factors were assessed every month for 4 months and the eCVD risk was calculated using the PROspective- Cardiovascular-Munster (PROCAM), Framingham, and Reynolds risk engines. Placebo had no significant effect on risk factors or eCVD risk. Mediterranean diet gradually induced a significant reduction in total cholesterol (TC), LDL-C, triglycerides, high sensitivity C-reactive protein (hsCRP), blood pressure and eCVD risk (24-32%). The plant stanol ester spread reduced (by 1 month) TC (-14%), LDL-C (-16%), hsCRP (-17%), and estimated CVD risk (26-30%). eCVD risk reduction was sustained at 4th months when the gradual Mediterranean diet eCVD risk reduction became comparable to that of the stanol group.Conclusions: Plant stanol esters yielded an early, by 1st treatment month, reduction of eCVD risk that resulted from a TC, LDL-C, and hsCRP decrease. eCVD risk reduction on the Mediterranean diet resulted from a change in several CVD risk factors and equaled that of plant stanol at 4 months. The consumption of plant stanol esters by moderately hypercholesterolaemic patients may be a useful option to reduce CVD risk in those who do not adopt a Mediterranean diet. (C) 2009 Elsevier B.V. All rights reserved.