Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation
Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation
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DOI：
10.1016/j.clnu.2013.07.012
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发表时间：
2014-06-01
影响因子：
6.3
通讯作者：
Bouteloup, Corinne
中科院分区：
文献类型：
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作者：
Guieze, Romain;Lemal, Richard;Bouteloup, Corinne
背景：同种异体造血干细胞移植（allo-HSCT）与频繁且严重的营养不良有关，这可能导致移植相关的发病率。虽然通过鼻胃管的肠内营养 (EN) 和肠外营养 (PN) 均有效，但目前尚不清楚什么是营养支持的最佳方法。 目的：我们建议比较 EN 与 PN 对 allo-HSCT 后早期结局的影响。 方法：我们评估了 56 名在我们中心因血液系统恶性肿瘤首次异基因 HSCT 后需要营养支持的患者，EN 与 PN 初始营养支持对早期结局的影响。患者接受了 EN 治疗，但可能会拒绝并选择接受 PN 治疗。结果：20 名患者接受清髓性预处理，36 名患者接受降低强度预处理。 28 名患者接受 EN 治疗，28 名患者接受 PN 治疗。与 PN 相比，EN 与较低的中位发热持续时间相关（2 天与 5 天；p
Background: Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) is associated with frequent and severe malnutrition, which may contribute to transplant-related morbidity. While both enteral nutrition (EN) via a nasogastric tube and parenteral nutrition (PN) are effective, it remains unclear what is the optimal method of nutritional support.Aims: We propose to compare the impact of EN versus PN on early outcome after allo-HSCT.Methods: We evaluated the effect of initial nutritional support with EN versus PN on early outcome in 56 patients who required nutritional support after first allo-HSCT for haematological malignancies in our centre. Patients were offered EN but could decline and chose to be treated by PN.Results: Twenty patients received myeloablative conditioning and 36 received reduced-intensity conditioning. Twenty-eight patients received EN and 28 received PN. Compared with PN, EN was associated with a lower median duration of fever (2 versus 5 days; p