PRESYNAPTIC EFFECT OF CLONIDINE ON UNMYELINATED AFFERENT-FIBERS IN THE SPINAL-CORD OF THE CAT
PRESYNAPTIC EFFECT OF CLONIDINE ON UNMYELINATED AFFERENT-FIBERS IN THE SPINAL-CORD OF THE CAT
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DOI：
10.1016/0304-3940(86)90351-4
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发表时间：
1986-03-14
影响因子：
2.5
通讯作者：
GHIGNONE, M
中科院分区：
文献类型：
--
作者：
CALVILLO, O;GHIGNONE, M
研究了可乐定 (Clo) 对皮肤来源的 A 纤维和 C 纤维脊髓内初级传入末梢兴奋性的影响。通过向用戊巴比妥麻醉的急性脊髓化猫的背角提供恒定电流脉冲来测试初级传入末梢兴奋性。 Clo 静脉注射选择性地增加 C 纤维初级传入末梢的兴奋性（平均 85%）。 A 纤维的初级传入末梢兴奋性不受影响。 Clo的这种作用被育亨宾或酚妥拉明逆转，因此表明由α2-肾上腺素受体介导。这些发现表明 Clo 在脊髓伤害感受通路中具有突触前抑制作用，这可能解释了该药物的作用机制。
The effects of clonidine (Clo) were investigated on the excitability of intraspinal primary afferent terminals of both A- and C-fibers of cutaneous origin. Primary afferent terminal excitability was tested by delivering constant current pulses to the dorsal horn of acutely spinalized cats anesthetized with pentobarbital. Clo given i.v. selectively increased the excitability of the C-fiber primary afferent terminals (mean 85%). Primary afferent terminal excitability of A-fibers was not affected. This effect of Clo was reversed by yohimbine or phentolamine, thus suggesting mediation by .alpha.2-adrenoceptors. These findings suggest a presynaptic inhibitory effect of Clo in spinal nociceptive pathways that might explain the mechanism of action of this drug.