Genomic dark matter sheds light on EVI1-driven leukemia.

Genomic dark matter sheds light on EVI1-driven leukemia.
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基因组暗物质揭示了 EVI1 驱动的白血病。

DOI:
10.1016/j.ccr.2014.03.031
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发表时间:
2014
期刊:
影响因子:
50.3
通讯作者:
Armstrong,ScottA
Armstrong,ScottA
中科院分区:
医学1区
文献类型:
--
作者:
Koche,RichardP;Armstrong,ScottA

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转录程序的编排依赖于适当的基因-增强子配对。虽然在正常发育过程中仍有很多需要了解的,但最近在Cell(Gröschel及其同事)和Cancer Cell(Yamazaki及其同事)上的两项研究强调了增强子的基因组重排如何在白血病发生程序的发生中发挥因果作用。
The orchestration of transcriptional programs depends on proper gene-enhancer pairing. While much remains to be learned about this process in normal development, two recent studies inCell(Gröschel and colleagues) and this issue ofCancer Cell(Yamazaki and colleagues) highlight how the genomic rearrangement of an enhancer plays a causal role in the onset of a leukemogenic program.
DOI: 10.1016/j.cell.2014.02.019
发表时间: 2014-04-10
期刊: CELL
影响因子: 64.5
作者:
Groeschel, Stefan;Sanders, Mathijs A.;Delwel, Ruud
通讯作者: Delwel, Ruud