Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark.
Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark.
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DOI：
10.1203/pdr.0b013e3181cbd564
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发表时间：
2010-03
影响因子：
3.6
通讯作者：
Finnell RH
中科院分区：
文献类型：
--
作者：
Bille C;Pedersen DA;Andersen AM;Mansilla MA;Murray JC;Christensen K;Ballard JL;Gorman EB;Cabrera RM;Finnell RH
本研究的目的是确定孕妇体内抗叶酸受体α（FRα）的免疫球蛋白G（IgG）和M（IgM）自身抗体是否与受唇裂影响的后代风险增加相关。在前瞻性丹麦国家出生队列（100，418例妊娠，1997-2003年入组）中进行了一项病例对照研究。185名儿童出生时患有唇裂。将来自其母亲（病例）的母体血清与来自779名随机选择的非畸形儿童母亲（对照）的母体血清进行比较。我们发现，FRα IgG自身抗体的平均水平在病例组和对照组之间没有显著差异（p=0.71）。对照组FRα IgM自身抗体水平略高于病例组。然而，这是没有统计学意义（p=0.06），除了孤立性唇裂儿童的母亲（p=0.04）。叶酸受体与叶酸结合的阻断在病例组和对照组中相似（p=0.54）。结果并没有改变时，分层到唇腭裂亚组，也没有单独的口腔唇腭裂病例被认为是。总之，在该人群队列中，妊娠期间母体血清中高水平的自身抗体和叶酸与叶酸受体α结合的阻断与后代口裂风险增加无关。
The objective of this study was to determine whether Immunoglobulin G (IgG) and M (IgM) autoantibodies to folate receptor α (FRα) in pregnant women are associated with an increased risk of oral cleft-affected offspring. A case-control study nested in the prospective Danish National Birth Cohort (100,418 pregnancies, enrolled during 1997–2003) was done. 185 children were born with an oral cleft. Maternal serum from their mothers (cases) was compared to maternal serum from 779 randomly selected mothers of non-malformed children (controls). We found that the average level of FRα IgG autoantibodies did not differ significantly among cases and controls (p=0.71). Slightly higher levels of FRα IgM autoantibodies were found among controls compared to cases. This was, however, not statistically significant (p=0.06), except for mothers of children with isolated cleft lip (p=0.04). Blocking of folate binding to folate receptor was similar among cases and controls (p=0.54). The results did not change when stratifying into the cleft subgroups, nor when only isolated oral cleft cases were considered. In conclusion, high maternal autoantibody levels and blocking of folate binding to folate receptor α in maternal serum during pregnancy are not associated with an increased risk of oral clefts in the offspring in this population based cohort.