Rapid calcium mobilization by vasopressin and prostaglandin F2 alpha is independent of sodium influx in quiescent 3T3 cells.

Rapid calcium mobilization by vasopressin and prostaglandin F2 alpha is independent of sodium influx in quiescent 3T3 cells.
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加压素和前列腺素 F2 α 引起的快速钙动员与静止 3T3 细胞中的钠流入无关。

DOI:
10.1016/0006-291x(84)90301-2
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发表时间:
1984
影响因子:
3.1
通讯作者:
L. Smith
L. Smith
中科院分区:
生物学4区
文献类型:
--
作者:
J. Smith;L. Smith

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加压素(VP)可迅速增加45 Ca ~(2+)外流。VP拮抗剂阻止VP动员Ca 2+和刺激DNA合成。前列腺素F2α(PGF 2 α)也刺激45 Ca 2+的快速释放。不同野牡丹素的有效性对应于它们作为有丝分裂原的有效性。去除细胞外Na+或Ca ~(2+)对VP-或PGF_(2 α)诱导的~(45)Ca ~(2+)释放无影响。目前的结果表明,这些激素的细胞内Ca ~(2+)的动员是独立的Na ~+或Ca ~(2+)内流和Ca ~(2+)动员是重要的生长刺激。
Vasopressin (VP) rapidly increased45Ca2+efflux. A VP antagonist prevented VP from mobilizing Ca2+and stimulating DNA synthesis. Prostaglandin F2α(PGF2α) also stimulated rapid45Ca2+release. The effectiveness of different prostaglandins corresponded to their effectiveness as mitogens. The removal of external Na+or Ca2+had no effect on VP-or PGF2α-induced45Ca2+release. The present results indicate that the mobilization of intracellular Ca2+by these hormones is independent of Na+or Ca2+influx and that Ca2+mobilization is important for growth stimulation.
分离和培养的肝细胞中加压素诱导的肌醇脂质变化的定量和早期动力学。
DOI: --
发表时间: 1983
期刊: The Journal of biological chemistry
影响因子: --
作者:
Thomas,AP;Marks,JS;Coll,KE;Williamson,JR
通讯作者: Williamson,JR