Inositol 1,4,5-trisphosphate directly opens diphtheria toxin channels.
Inositol 1,4,5-trisphosphate directly opens diphtheria toxin channels.
复制标题
肌醇1,4,5-三磷酸直接打开白喉毒素通道。
DOI：
10.1016/0005-2736(91)90116-p
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kagan,BL
中科院分区：
文献类型：
--
作者：
Kagan,BL
Inositol 1,4,5-triphosphate (IP3) is a soluble messenger, which acts by cooperatively releasing Ca2+into the cytosol from non-mitochondrial stores, probably by activating Ca2+-permeable channels. We demonstrate that submicromolar concentrations of IP3can directly open the Ca2+-permeable diphtheria toxin channel, and that this occurs by IP3binding to a specific site on the toxin protein. This provides a model for IP3-induced Ca2+release and suggests that IP3-induced channel opening may play a role in diphtheria intoxication and in protein translocation across membranes.
