Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study
Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study
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DOI：
10.1016/j.ijheh.2018.05.015
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发表时间：
2018-07-01
影响因子：
6
通讯作者：
Bouchard, Maryse F.
中科院分区：
文献类型：
--
作者：
Ashley-Martin, Jillian;Dodds, Linda;Bouchard, Maryse F.
流行病学研究假设，怀孕期间血锰（Mn）水平不足和过量均与胎儿生长发育迟缓有关。这篇文献的特点是不一致的结果和有限的重点妇女代表一般北美人口的暴露。我们研究了母亲和脐带血锰水平和胎儿生长的妇女参加了母婴研究环境化学品研究（MIREC）之间的关系。有单胎、足月婴儿和完整的母体妊娠早期和妊娠晚期血锰数据的母亲有资格入选本研究（n = 1519）。根据母亲和脐带血Mn水平（低（< 10），参考（10- < 90），高（>= 90）毫克）估计平均出生体重和小于胎龄儿（SGA）出生的比值比。我们还评估了脐带血和母血锰的比值与出生体重之间的关系。母亲血液中锰水平低（< 0.82 μ g/dL）的孕妇所生婴儿的平均体重比参考暴露组孕妇所生婴儿的平均体重轻64.7 g（95%CI：-142.3，12.8）。当校正有毒金属（铅、汞、砷和镉）83.3 g（95% CI：-162.4，-4.1）时，这种关联得到加强，并具有统计学显著性。在母体妊娠早期或脐带血Mn模型中未观察到统计学显著相关性。当校正母体和新生儿特征时，脐带血/母体血Mn比值增加一个单位与29.4 g相关（95%CI：-50.2，-8.7）。我们的发现激发了更多关于锰暴露与胎儿生长之间关系的研究。有必要进行进一步调查，以确定是否存在暴露阈值，母体和胎儿锰的生长相关影响可能有何不同，以及同时暴露于其他有毒金属可能如何影响锰和生长之间的关联。
Epidemiological studies have hypothesized that both insufficient and excess blood manganese (Mn) levels during pregnancy are associated with reduced fetal growth. This literature is characterized by inconsistent results and a limited focus on women with exposures representative of the general North American population. We examined the relationship between maternal and cord blood Mn levels and fetal growth among women enrolled in the Maternal-Infant Research on Environmental Chemicals Study (MIREC). Mothers with singleton, term infants and complete maternal first and third trimester blood Mn data were eligible for inclusion in the present study (n = 1519). Mean birth weight and odds ratios of small for gestational age (SGA) births according to maternal and cord blood Mn levels (low (< 10), referent (10- < 90), high (>= 90) percentiles) were estimated. We also evaluated the association between the ratio of cord and maternal blood Mn and birth weight. Women with low (< 0.82 mu g/dL) maternal blood third trimester Mn levels had infants that weighed an average of 64.7 g (95% CI: -142.3,12.8) less than infants born to women in the referent exposure group. This association was strengthened and became statistically significant when adjusted for toxic metals (lead, mercury, arsenic, and cadmium) 83.3 g (95% CI: -162.4, -4.1)]. No statistically significant associations were observed in models of maternal first trimester or cord blood Mn. A one unit increase in the cord/maternal blood Mn ratio was associated with a 29.4 g (95% CI: -50.2, -8.7), when adjusted for maternal and neonatal characteristics. Our findings motivate additional research regarding the relation between Mn exposure and fetal growth. Further inquiry is necessary to determine whether an exposure threshold exists, how growth related effects of maternal and fetal Mn may differ, and how concurrent exposure to other toxic metals may impact the association between Mn and growth.