Phases of diabetes
Phases of diabetes
复制标题
DOI：
10.1111/j.1399-5448.2006.00225.x
复制
发表时间：
2007-02
影响因子：
3.4
通讯作者：
J. Couper;K. Donaghue
中科院分区：
文献类型：
--
作者：
J. Couper;K. Donaghue
任何人群的筛查或临床前阶段的干预都不应发生在定义的临床研究背景之外（7）。筛查T1DM遗传或免疫学标志物阳性的个体应获得适当的咨询，并参加干预和其他定义研究的中心。干预性研究应登记为国际调查网络的一部分，有关正在进行的研究的信息应随时可用（7，8）。T1DM的一个已证实的环境触发因素是先天性风疹（9，10）。其他潜在的环境触发因素包括肠道病毒感染（11）、酪蛋白（12）和谷物（麸质或非麸质）（13，14）。低水平的并发感染和改善卫生可能与风险增加有关（15）。加速（而不是触发）β细胞的假说
Neither screening of any population nor intervention in the preclinical phase should occur outside the context of defined clinical studies (7). Individuals who screen positive for genetic or immunological markers of T1DM should have access to appropriate counselling and to centres participating in intervention and other defined studies. Intervention studies should be registered as part of an international network of investigation and information about ongoing studies should be readily available (7, 8). The one proven environmental trigger of T1DM is congenital rubella (9, 10). Other potential environmental triggers are enteroviral infections (11), casein (12), and cereals (gluten or non gluten) (13, 14). Low levels of intercurrent infection and improved hygiene may be associated with increased risk (15). The hypothesis of acceleration (rather than triggering) of beta-cell