Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
复制标题
DOI：
10.1101/gad.279737.116
复制
发表时间：
2016-05-01
影响因子：
10.5
通讯作者：
Tlsty TD
中科院分区：
文献类型：
--
作者：
Gascard P;Tlsty TD
在这篇综述中，Gascard和Tlsty专注于癌症相关成纤维细胞（CAFs）对疾病进展的贡献的新见解。他们还讨论了CAF的产生和最近的治疗方法，旨在钝化或恢复与CAF相关的有害的促肿瘤表型。肿瘤间质不再仅仅被视为突变上皮细胞的物理支持，而是重要的调节剂，甚至是致瘤性的驱动因素。在肿瘤间质环境中，成纤维细胞样细胞的异质群体，统称为癌相关成纤维细胞（CAF），是多细胞，基质依赖性改变的关键参与者，有助于恶性肿瘤的发生和发展。本文综述了CAF对疾病进展的贡献、导致CAF产生的紧急事件、预测疾病结局的CAF特异性生物标志物的鉴定以及最近旨在钝化或逆转与CAF相关的有害促肿瘤表型的治疗方法。
In this review, Gascard and Tlsty focus on novel insights into the contributions of carcinoma-associated fibroblasts (CAFs) to disease progression. They also discuss the generation of CAFs and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs. The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but as an important modulator and even a driver of tumorigenicity. Within the tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed carcinoma-associated fibroblasts (CAFs), are key players in the multicellular, stromal-dependent alterations that contribute to malignant initiation and progression. This review focuses on novel insights into the contributions of CAFs to disease progression, emergent events leading to the generation of CAFs, identification of CAF-specific biomarkers predictive of disease outcome, and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs.