Elevated transrenal DNA (cell-free urine DNA) in patients with urinary tract infection compared to healthy controls
Elevated transrenal DNA (cell-free urine DNA) in patients with urinary tract infection compared to healthy controls
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DOI：
10.1016/j.clinbiochem.2008.12.021
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发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
Alvarez Menendez, Francisco V.
中科院分区：
文献类型：
--
作者：
Garcia Moreira, Vanessa;Prieto Garcia, Belen;Alvarez Menendez, Francisco V.
目的：目的：探讨尿路感染（UTI）是否影响肾细胞跨肾DNA（Tr-DNA）水平。结果：UTI患者血清中DNA浓度高于正常人（正常范围：0-147 GE/mL）。QIAamp MiniElute Virus Spin Kit比QIAamp DNA Blood Mini Kit更有效。结论：在UTI存在的情况下，Tr-DNA尿DNA浓度增加。(C)2008年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: To study whether levels of transrenal DNA (Tr-DNA) are influenced by the presence of urinary tract infections (UTI).Methods: Tr-DNA concentrations were measured in 124 donors and 55 patients with UTI. Two methods for DNA extraction were compared.Results: UTI patients showed higher concentrations than the donors (normal range: 0-147 GE/mL). QIAamp MiniElute Virus Spin Kit was more efficient than QIAamp DNA Blood Mini Kit.Conclusion: Increased concentrations of Tr-DNA urine DNA are shown in presence of UTI. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.