Cost-effectiveness of a package of interventions for expedited antiretroviral therapy initiation during pregnancy in Cape Town, South Africa.
Cost-effectiveness of a package of interventions for expedited antiretroviral therapy initiation during pregnancy in Cape Town, South Africa.
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DOI：
10.1007/s10461-013-0641-7
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发表时间：
2014-04
影响因子：
4.4
通讯作者：
Myer, Landon
中科院分区：
文献类型：
--
作者：
Zulliger, Rose;Black, Samantha;Holtgrave, David R.;Ciaranello, Andrea L.;Bekker, Linda-Gail;Myer, Landon
关键词：
Initiating antiretroviral therapy (ART) early in pregnancy is an important component of effective interventions to prevent the mother-to-child transmission of HIV (PMTCT). The Rapid initiation of ART in Pregnancy (RAP) program was a package of interventions to expedite ART initiation in pregnant women in Cape Town, South Africa. Retrospective, cost-effectiveness, sensitivity and threshold analyses were conducted of the RAP program to determine the cost-utility thresholds for rapid initiation of ART in pregnancy. Costs were drawn from a detailed microcosting of the program. The overall programmatic cost was US$880 per woman and the base case cost-effectiveness ratio was US$1,160 per quality-adjusted life year (QALY) saved. In threshold analyses, the RAP program remained cost-effective if mother-to-child transmission was reduced by ≥0.33%; if ≥1.76 QALY were saved with each averted perinatal infection; or if RAP-related costs were under US$4,020 per woman. The package of rapid initiation services was very cost-effective, as compared to standard services in this setting. Threshold analyses demonstrated that the intervention required minimal reductions in perinatal infections in order to be cost-effective. Interventions for the rapid initiation of ART in pregnancy hold considerable potential as a cost-effective use of limited resources for PMTCT in sub-Saharan Africa.
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影响因子：
3.7
作者：
Fasawe, Olufunke;Avila, Carlos;De Lay, Paul
通讯作者：
De Lay, Paul
DOI：
10.1186/1478-7547-9-3
发表时间：
2011-02-09
期刊：
Cost effectiveness and resource allocation : C/E
影响因子：
--
作者：
Johri, Mira;Ako-Arrey, Denis
通讯作者：
Ako-Arrey, Denis
DOI：
10.1080/09540121.2012.668173
发表时间：
2012-01-01
影响因子：
1.7
作者：
Myer, Landon;Zulliger, Rose;Bekker, Linda-Gail
通讯作者：
Bekker, Linda-Gail
影响因子：
3.1
作者：
Myer L;Zulliger R;Bekker LG;Abrams E
通讯作者：
Abrams E
DOI：
10.1097/qai.0b013e3181eef4d3
发表时间：
2010-11-01
影响因子：
3.6
作者：
Robberstad, Bjarne;Evjen-Olsen, Bjorg
通讯作者：
Evjen-Olsen, Bjorg