NERVOUS-SYSTEM DYSFUNCTION AMONG WORKERS WITH LONG-TERM EXPOSURE TO MANGANESE
NERVOUS-SYSTEM DYSFUNCTION AMONG WORKERS WITH LONG-TERM EXPOSURE TO MANGANESE
复制标题
DOI：
10.1006/enrs.1994.1013
复制
发表时间：
1994-02-01
影响因子：
8.3
通讯作者：
MARTIN, L
中科院分区：
文献类型：
--
作者：
MERGLER, D;HUEL, G;MARTIN, L
神经系统疾病与帕金森病有许多相似之处，与环境和职业暴露于锰（Mn）有关。为了记录与长期暴露于锰相关的早期神经系统功能障碍，对锰合金生产中雇用的工人进行了一系列神经功能测试。研究参与率为95%（n = 115）。采用配对设计;从该地区招募积极工作的男性，没有工作场所暴露于神经毒素的历史作为参考。匹配的变量包括：年龄（+/-3岁）、教育水平（+/-2岁）、吸烟状况和子女数量。固定环境取样表明，锰含量变化很大（几何平均值：锰尘，0.89毫克/立方米;可吸入锰，0.04毫克/立方米）。合金工人的全血锰水平显著较高（几何平均值：1.03 μ g/100 ml vs 0.68 μ g/100 ml）;尿锰无差异。单变量分析（配对t检验，符号秩和McNemar）和多变量方差分析（Hotelling-Lawley统计）显示，对不同的症状报告，情绪状态，运动功能，认知灵活性，嗅觉感知阈值;语言流畅性，基础数学，阅读能力，注意力是相似的。这些研究结果是一致的，与目前的知识，大脑锰活动，并建议早期锰中毒的表现，可以观察到在精心设计的人口研究，使用敏感的测试方法。(C)1994年出版社出版。
Neurological disorders, bearing many similarities to Parkinson's disease, have been associated with environmental and occupational exposure to manganese (Mn). To document early nervous system dysfunction associated with long-term exposure to Mn, a battery of neurofunctional tests was administered to workers employed in Mn alloy production. Study participation was 95% (n = 115). A matched pair design was used; actively working men, with no history of workplace exposure to neurotoxins, were recruited from the region as referents. Matching was done on the variables: age (+/-3 years), educational level (+/-2 years), smoking status, and number of children. Stationary environmental sampling indicated that Mn levels varied widely (geometric means: Mn dust, 0.89 mg/m(3); respirable Mn, 0.04 mg/ m(3)). The alloy workers had significantly higher levels of whole blood Mn (geometric mean: 1.03 mu g/100 ml vs 0.68 mu g/100 ml); no differences were observed for urinary Mn. Univariate analysis (paired t test, Signed Rank and McNemar) and multivariate analysis of variance (Hotelling-Lawley statistic) revealed that the pairs differed on symptom reporting, emotional state, motor functions, cognitive flexibility, and olfactory perception threshold; verbal fluency, basic mathematics, reading capability, and attentional capacity were similar. These findings are consistent with current knowledge on brain Mn activity and suggest that manifestations of early manganism can be observed in well designed population studies, using sensitive testing methods. (C) 1994 Academic Press, Inc.