Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population
Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population
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DOI：
10.1038/sj.jhh.1001983
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发表时间：
2006-04-01
影响因子：
2.7
通讯作者：
Bolek, L
中科院分区：
文献类型：
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作者：
Mayer, O;Filipovsky, J;Bolek, L
总同型半胱氨酸（tHcy）水平被确定为心血管事件的强有力且独立的预测因素。我们在一个随机的、基于一般人群的251名受试者（平均年龄48岁）的样本中调查了tHcy和大动脉机械性能之间的关系。大动脉特性，如主动脉和外周（下肢）脉搏波速度（PWV）和桡动脉的增强指数，使用半自动Sphygmocor（R）设备进行测量。主动脉PWV（APWV）与tHcy呈正相关（r = 0.28，P < 0.0001），tHcy四分位数分析显示APWV呈显著增加趋势（ANOVA分析P = 0.0003）。在校正了传统的心血管危险因素（年龄、性别、吸烟、超重、高血压、血脂异常和糖代谢受损）和常见的同型半胱氨酸混杂因素（叶酸、B-12、肾功能）后，这种关联仍然显著。轻度高同型半胱氨酸血症受试者（i. e. tHcy >= 15 μ mol/ l）的APWV超过8.42 m/ s的风险高2.74倍（i. e.在前四分之一）。无论是下肢PWV测量还是桡动脉扩张指数，都没有发现这种相关性。总之，在我们来自普通人群的一系列受试者中，我们发现同型半胱氨酸浓度与APWV（中央动脉僵硬度的参数）之间存在强烈且独立的关系。
Total homocysteine ( tHcy) level was identified as a strong and independent predictor of cardiovascular events. We investigated the association between tHcy and mechanical properties of large arteries in a random, general population- based sample of 251 subjects ( mean age 48 years). Large artery properties, such as aortic and peripheral ( lower- limb) pulse wave velocity ( PWV), and augmentation index of radial artery were measured using semi- automatic Sphygmocor (R) device. Aortic PWV ( APWV) positively correlated with tHcy ( r = 0.28, P < 0.0001), and a significant increasing trend of APWV was found by tHcy quartiles ( P = 0.0003 by ANOVA). This association remained significant after adjustment for conventional cardiovascular risk factors ( age, gender, smoking, overweight, hypertension, dyslipidaemia and impaired glucose metabolism) and for usual homocysteine confounders ( folate, B-12, renal function). Subjects with mild hyperhomocysteinaemia ( i. e. with tHcy >= 15 mu mol/ l) had 2.74 times higher risk of having their APWV over 8.42 m/ s ( i. e. in the top quartile). No such association was found either for PWV measured at lower extremity or for radial augmentation index. In conclusion, in our series of subjects from general population, we found a strong and independent relationship between homocysteine concentration and APWV, a parameter of stiffness of central arteries.