Design and application of a new rat-specific vacuum erectile device for penile rehabilitation research.
Design and application of a new rat-specific vacuum erectile device for penile rehabilitation research.
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DOI：
10.1111/j.1743-6109.2009.01500.x
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Jiuhong Yuan;O. Westney;Run Wang
中科院分区：
文献类型：
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作者：
Jiuhong Yuan;O. Westney;Run Wang
引言根治性阴茎切除术对阴茎健康有潜在的负面影响。真空勃起装置（VED）已被用于促进阴茎功能的恢复和保持阴茎长度。然而，由于其在阴茎康复中的机制难以捉摸，泌尿外科界对此持怀疑态度。目的设计一种大鼠特异性VED，并对其应用和安全性进行评价。方法在大鼠阴茎测量的基础上，结合人体VED原理，设计大鼠专用VED，并进行大鼠应用评价。主要观察指标：测定大鼠专用VED的真空压力。对VED在大鼠阴茎上的应用及其副作用进行了研究。结果大鼠专用VED是一种安全、适用于研究VED在阴茎再造中作用机制的装置。结论：新设计的大鼠专用VED是一个很好的模拟人VED的模型。本研究将通过建立双侧海绵体神经损伤大鼠模型，探讨VED在阴茎康复中的作用机制。
INTRODUCTION Radical prostatectomy has a potential negative impact on penile health. The vacuum erection device (VED) has been used to promote the recovery of penile function and to maintain penile length. However, there is skepticism in the urological community due to its elusive mechanisms in penile rehabilitation. AIM To design a rat-specific VED and assess its application and safety. METHODS Based on rat penile measurement and the principle of human VED, the rat-specific VED was designed, and the application for rats was evaluated. MAIN OUTCOME MEASURES The vacuum pressure of the rat-specific VED was measured. The VED application on rat penis and its side effects were studied. RESULTS The rat-specific VED is a safe and applicable device to study the mechanism of VED in penile rehabilitation. CONCLUSIONS The newly designed rat-specific VED is a good simulator of the human VED. The application of this device on bilateral cavernous nerve crush rat model will be used to study the mechanisms of the VED in the penile rehabilitation.