68Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
68Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer
复制标题
68Ga-成纤维细胞激活蛋白抑制剂PET/CT对食管癌放疗规划中肿瘤体积勾画的影响
DOI：
10.1016/j.radonc.2021.02.015
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发表时间：
2021-03-04
影响因子：
5.7
通讯作者：
Lin, Qin
中科院分区：
文献类型：
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作者：
Zhao, Liang;Chen, Shanyu;Lin, Qin
背景和目的：比较Ga-68-成纤维细胞活化蛋白抑制剂（FAPI）和F-18-FDG PET/ CT在局部晚期食管癌成像中的作用，并评价Ga-68-FAPI PET/CT与对比增强CT（CE-CT）和F-18-FDG PET/CT相比在食管癌放射治疗计划中勾画大体靶区（GTV）的潜在价值。材料和方法：选择21例新诊断的食管癌患者，他们接受了F-18-FDG和Ga-68-FAPI PET/CT扫描。描述了基于CE-CT（GTV（CT））、PET/CT和CE-CT + PET/CT的原发性肿瘤的GTV。通过GTV和内窥镜检查测量肿瘤的总长度并记录。结果：Ga-68-FAPI PET显示原发性肿瘤的放射性示踪剂摄取显著高于F-18-FDG PET（中位数SUVmax 16.71 vs. 11.23; P = 0.002）。FAPI x 20%、30%、40%和FDG x 40%的SUV阈值显示病变长度与内镜检查结果相似（P > 0.05）。GTV（CT）显示的体积最大（中位数：48.80 mm（3），范围：14.83-162.23 mm（3））。对于PET/CT引导的GTV（CT）补充轮廓，4例患者（19%）的FAPI增加了20%和30%，2例患者（9.5%）的FAPI增加了40%，仅1例患者的FDG增加了40%。此外，基于CE-CT + FAPI x20%、30%和40%的GTV体积与基于CE-CT + FAPI-PET的GTV（CT）和计划靶体积无显著差异，符合危险器官标准。Ga-68-FAPI PET/CT方法显示了有利的肿瘤-食管癌的背景对比度，并可能为靶体积描绘提供额外的信息，并有助于避免肿瘤地理遗漏。(C)2021作者由爱思唯尔公司出版
Background and purpose: To compare Ga-68-fibroblast activation protein inhibitor (FAPI) and F-18-FDG PET/ CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of Ga-68-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and F-18-FDG PET/CT.Materials and methods: Twenty-one patients with newly diagnosed oesophageal cancer who underwent both F-18-FDG and Ga-68-FAPI PET/CT scans were selected. GTVs of the primary tumours based on CE-CT (GTV(CT)), PET/CT, and CE-CT plus PET/CT were delineated. Gross tumour lengths were measured by GTVs and endoscopy and recorded.Results: The Ga-68-FAPI PET showed significantly higher radiotracer uptake than F-18-FDG PET (median SUVmax 16.71 vs. 11.23; P = 0.002) in the primary tumours. SUV thresholds of FAPI x20%, 30%, 40%, and FDG x40% showed similar lesion lengths compared with that in endoscopic examination (P > 0.05). GTV(CT) demonstrated the largest volume (median: 48.80 mm(3), range: 14.83-162.23 mm(3)) than PET-based GTVs. For PET/CT-guided complementary contouring of GTV(CT), four patients (19%) were increased by FAPI x20% and 30%, two patients (9.5%) were increased by FAPI x40%, and only one patient was increased by FDG x40%. Furthermore, the volume of GTV based on CE-CT plus FAPI x20%, 30%, and 40% showed no significant difference with GTV(CT) and planning target volume based CE-CT plus FAPI-PET and meets the organ at risk standard.Conclusion: The Ga-68-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses. (C) 2021 The Authors. Published by Elsevier B.V.