A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon.
A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon.
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DOI：
10.1186/1476-069x-5-29
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发表时间：
2006-10-10
期刊：
影响因子：
--
通讯作者：
Guimaraes, Jean Remy Davee
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文献类型：
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作者：
Fillion, Myriam;Mergler, Donna;Guimaraes, Jean Remy Davee
背景：鱼类被认为对冠心病（CHD）有保护作用，但从鱼类中摄入汞（Hg）可能会抵消其有益作用。虽然甲基汞（MeHg）的神经毒性作用已得到证实，但其对心血管的影响仍存在争议。本研究的目的是评估巴西亚马逊地区非本地食鱼人群中汞暴露和鱼类消费与血压的关系。方法：研究对象是来自亚马逊河主要支流塔帕霍斯河沿岸6个社区的251人。获得社会人口统计信息、鱼类消费、身高和体重数据，以确定体重指数（BMI）、收缩压和舒张压以及头发样本中的汞浓度。结果：结果显示，总体收缩压和舒张压相对较低（平均：113.9 mmHg +/- 14.6和73.7 mmHg +/- 11.0）。血压与头发总汞含量（H-Hg）、年龄、体重指数和性别显著相关。鱼类消费和血压之间没有关联，尽管在社区间存在显著差异。Logistic回归分析显示，考虑年龄、BMI、吸烟、性别和社区因素，H-Hg >或= 10 μ g/g时收缩压升高（>或= 130 mmHg）的比值比（OR）为2.91[1.26-7.28]。结论：本初步研究结果进一步支持了汞的心血管毒性。
BACKGROUND: Fish is considered protective for coronary heart disease (CHD), but mercury (Hg) intake from fish may counterbalance beneficial effects. Although neurotoxic effects of methylmercury (MeHg) are well established, cardiovascular effects are still debated. The objective of the present study was to evaluate blood pressure in relation to Hg exposure and fish consumption among a non-indigenous fish-eating population in the Brazilian Amazon.METHODS: The study was conducted among 251 persons from six communities along the Tapajos River, a major tributary of the Amazon. Data was obtained for socio-demographic information, fish consumption, height and weight to determine body mass index (BMI), systolic and diastolic blood pressure, and Hg concentration in hair samples.RESULTS: Results showed that overall, systolic and diastolic blood pressure, were relatively low (mean: 113.9 mmHg +/- 14.6 and 73.7 mmHg +/- 11.0). Blood pressure was significantly associated with hair total Hg (H-Hg), age, BMI and gender. No association was observed between fish consumption and blood pressure, although there were significant inter-community differences. Logistic regression analyses showed that the Odds Ratio (OR) for elevated systolic blood pressure (> or = 130 mmHg) with H-Hg > or = 10 microg/g was 2.91 [1.26-7.28], taking into account age, BMI, smoking, gender and community.CONCLUSION: The findings of this preliminary study add further support for Hg cardiovascular toxicity.